文献类型：期刊文献

英文题名：Actin-Binding Proteins as Potential Biomarkers for Chronic Inflammation-Induced Cancer Diagnosis and Therapy

作者：Zhang, Yu-Gui[1,2];Niu, Jiang-Tao[1,2];Wu, Hong-Wei[1,2];Si, Xin-Lei[1,2];Zhang, Shu-Juan[1,2];Li, Dong-Hui[1,2];Bian, Tian-Tian[1,2];Li, Yue-Feng[1,2];Yan, Xing-Ke[3]

第一作者：张永刚

通信作者：Li, YF[1];Li, YF[2];Yan, XK[3]

机构：[1]Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Peoples R China;[2]Gansu Univ Chinese Med, Engn Res Ctr Chinese Med Pharmaceut Proc Gansu, Key Lab Stand & Qual Chinese Med Res Gansu, Lanzhou 730000, Peoples R China;[3]Gansu Univ Chinese Med, Coll Acupuncture Moxibust & Tuina, Mol Biol Lab, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Engn Res Ctr Chinese Med Pharmaceut Proc Gansu, Key Lab Stand & Qual Chinese Med Res Gansu, Lanzhou 730000, Peoples R China;[3]corresponding author), Gansu Univ Chinese Med, Coll Acupuncture Moxibust & Tuina, Mol Biol Lab, Lanzhou 730000, Peoples R China.|[10735db5df93766a96e5b]甘肃中医药大学针灸推拿学院;[10735]甘肃中医药大学;[1073501e14fb35863569f]甘肃中医药大学药学院（西北中藏药协同创新中心办公室）;

年份：2021

卷号：2021

外文期刊名：ANALYTICAL CELLULAR PATHOLOGY

收录：;Scopus(收录号：2-s2.0-85108537882);WOS:【SCI-EXPANDED(收录号:WOS:000664841700002)】；

基金：This work was supported by the National Natural Science Foundation of China (Nos. 81960713 and 81460611), the Chinese Medicine Pharmaceutical Process Engineering Research Center Open Fund of Gansu (ZYGY202003), and the Gansu Provincial Key Laboratory of Quality and Standards for Traditional Chinese Medicine (ZYZL18-008).

语种：英文

摘要：Actin-binding proteins (ABPs), by interacting with actin, regulate the polymerization, depolymerization, bundling, and cross-linking of actin filaments, directly or indirectly, thereby mediating the maintenance of cell morphology, cell movement, and many other biological functions. Consequently, these functions of ABPs help regulate cancer cell invasion and metastasis when cancer occurs. In recent years, a variety of ABPs have been found to be abnormally expressed in various cancers, indicating that the detection and interventions of unusual ABP expression to alter this are available for the treatment of cancer. The early stages of most cancer development involve long-term chronic inflammation or repeated stimulation. This is the case for breast cancer, gastric cancer, lung cancer, prostate cancer, liver cancer, esophageal cancer, pancreatic cancer, melanoma, and colorectal cancer. This article discusses the relationship between chronic inflammation and the above-mentioned cancers, emphatically introduces relevant research on the abnormal expression of ABPs in chronic inflammatory diseases, and reviews research on the expression of different ABPs in the above-mentioned cancers. Furthermore, there is a close relationship between ABP-induced inflammation and cancer. In simple terms, abnormal expression of ABPs contributes to the chronic inflammation developing into cancer. Finally, we provide our viewpoint regarding these unusual ABPs serving as potential biomarkers for chronic inflammation-induced cancer diagnosis and therapy, and interventions to reverse the abnormal expression of ABPs represent a potential approach to preventing or treating the corresponding cancers.