文献类型：期刊文献

英文题名：Mechanisms of Peritoneal Mesothelial Cells in Peritoneal Adhesion

作者：Wang, Ruipeng[1];Guo, Tiankang[2,3];Li, Junliang[1,2,3]

第一作者：Wang, Ruipeng

通信作者：Li, JL[1];Li, JL[2];Li, JL[3]

机构：[1]Gansu Univ Chinese Med, Sch Clin Med 1, Lanzhou 730030, Peoples R China;[2]Gansu Prov Hosp, Dept Gen Surg, Lanzhou 730030, Peoples R China;[3]Lanzhou Univ, Sch Clin Med 1, Lanzhou 730030, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Clin Med 1, Lanzhou 730030, Peoples R China;[2]corresponding author), Gansu Prov Hosp, Dept Gen Surg, Lanzhou 730030, Peoples R China;[3]corresponding author), Lanzhou Univ, Sch Clin Med 1, Lanzhou 730030, Peoples R China.|[10735]甘肃中医药大学;

年份：2022

卷号：12

期号：10

外文期刊名：BIOMOLECULES

收录：;Scopus(收录号：2-s2.0-85140472584);WOS:【SCI-EXPANDED(收录号:WOS:000872249100001)】；

基金：This researchwas funded by the Natural Science Foundation of Gansu Province (20JR10RA372), the Health Industry Research Project of Gansu Province (GSWSKY-2019-03), the National Scientific Research Project Support Program of Gansu Provincial Hospital (19SYPYB-10), the Open Fund Project of Gansu Key Laboratory of Molecular Diagnosis and Precision Therapy of Surgical Oncology (2020GSZDSYS02), the Non-profit Central Research Institute Fund of the Chinese Academy of Medical Sciences (2019PT320005), the Scientific Research and Innovation Fund of Gansu University of Chinese Medicine (2020KCYB-7), the Research project of Traditional Chinese Medicine of Gansu Province (GZKP-2020-12), the Reform and practical exploration of the talent training model of "universityhospital co-construction" of education department of Gansu Province ((2021)5-6), the Longyuan Youth Innovation and Entrepreneurship Talent Project (111266548053), the Lanzhou Science and Technology Bureau particular project (2020-XG-3), and the 14th Five Year Plan of Education Science of Gansu Province (GS (2021) GHB1859).

语种：英文

外文关键词：peritoneal adhesions; peritoneal mesothelial cells; mesothelial-mesenchymal transition; inflammation; fibrosis

摘要：A peritoneal adhesion (PA) is a fibrotic tissue connecting the abdominal or visceral organs to the peritoneum. The formation of PAs can induce a variety of clinical diseases. However, there is currently no effective strategy for the prevention and treatment of PAs. Damage to peritoneal mesothelial cells (PMCs) is believed to cause PAs by promoting inflammation, fibrin deposition, and fibrosis formation. In the early stages of PA formation, PMCs undergo mesothelial-mesenchymal transition and have the ability to produce an extracellular matrix. The PMCs may transdifferentiate into myofibroblasts and accelerate the formation of PAs. Therefore, the aim of this review was to understand the mechanism of action of PMCs in PAs, and to offer a theoretical foundation for the treatment and prevention of PAs.