文献类型：期刊文献

英文题名：The gut microbiota-immune-brain axis in post-traumatic stress disorder: mechanistic integration and translational prospects

作者：Zheng, Xianli[1,2];Li, Dingpeng[3,4];Yao, Xiaoqiang[2];Luo, Xixi[2];Gao, Chunmei[2];Yan, Xingke[1,2]

第一作者：郑先丽

通信作者：Yan, XK[1];Yan, XK[2]

机构：[1]Gansu Univ Tradit Chinese Med, Lanzhou, Gansu, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Affiliated Hosp, Lanzhou, Gansu, Peoples R China;[3]Gansu Prov Second Peoples Hosp, Dept Orthoped, Lanzhou, Gansu, Peoples R China;[4]Northwest Minzu Univ, Affiliated Hosp, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Tradit Chinese Med, Affiliated Hosp, Lanzhou, Gansu, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2026

卷号：17

外文期刊名：FRONTIERS IN IMMUNOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001804643000001)】；

基金：The author(s) declared that financial support was received for this work and/or its publication. This work was supported by Gansu Provincial Health Industry Scientific Research Project (No. GSWSKY2022-61); Lanzhou Science and Technology Development Guidance Project (No. 2023-ZD-208); 2026 Clinical Key Specialty Capacity Improvement Project (Gan Cai [2025] No. 143); Gansu Provincial Acupuncture and Massage Clinical Medical Center Open Fund Project (No. ZJKF2202); Gansu Traditional Chinese Medicine Research High-Level Key Project (No. GZKZ-2025-27); Yao Xiaoqiang Gansu Famous Traditional Chinese Medicine Inheritance Studio (Gan Zhong Yi Yao Fa [2025] No. 4).

语种：英文

外文关键词：brain axis; gut microbiota; immunity; microbiota-gut-brain axis; neuroinflammation; post-traumatic stress disorder; translational medicine

摘要：Post-traumatic stress disorder (PTSD) is a complex mental disorder triggered by severe traumatic events. Its pathophysiology involves not only abnormalities in fear memory circuits and neuroendocrine imbalances but also immune dysregulation and alterations in gut homeostasis. In recent years, the gut microbiota, as a crucial regulatory factor connecting the periphery and the central nervous system, has garnered widespread attention for its potential role in the development and progression of PTSD, offering a new integrative perspective for understanding this disorder. This article focuses on the "gut microbiota-immune-brain axis" framework, reviewing evidence related to changes in the composition and function of the gut microbiota in PTSD. It summarizes how these changes may influence neuroplasticity abnormalities and PTSD-related behavioral phenotypes through mechanisms involving microbial metabolite production, modulation of intestinal barrier integrity, immuno-inflammatory responses, regulation of neuroendocrine homeostasis, and blood-brain barrier dysfunction. However, these mechanistic pathways remain incompletely validated in human studies. Existing research suggests that this axis holds significant value in explaining the multisystem pathological features of PTSD. Nevertheless, challenges persist, including ambiguous causal relationships in microbiota-host interactions, limited direct clinical evidence, and insufficient translational research. Current evidence primarily stems from observational studies, preclinical models, and preliminary intervention studies. The explanatory power varies across these evidence levels: population studies primarily establish correlations, animal models facilitate mechanistic validation, metagenomic and metabolic analyses yield functional insights, while clinical intervention data remain exploratory. This article aims to elucidate the key molecular and systemic mechanisms underlying this axis in PTSD and to evaluate the potential translational value and practical limitations of microbial intervention and immune modulation strategies.