文献类型：期刊文献

英文题名：Association between 5-hydroxytryptamine gene polymorphism rs140700 and primary insomnia in Chinese population

作者：Hui, Peilin[1];Yang, Jun[2];Wang, Jing[3];Zhao, Lijun[4];Wang, Xubin[1];Su, Xiaoyan[1];Wang, Jinfeng[1];Ma, Wei[1];Fan, Jie[1];Chen, Wenjuan[1];Zhao, Yuan[1];Guo, Bin[1];Liu, Yu[1];Zhang, Shangli[1];Zheng, Ning[1];Zhou, Liyan[1];Xie, Yuping[1]

第一作者：Hui, Peilin

通信作者：Xie, YP[1]

机构：[1]Gansu Univ Tradit Chinese Med, Sleep Med Ctr, Gansu Prov Hosp, Lanzhou, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Sch Chinese Tradit Med Integrated Western Med, Lanzhou, Peoples R China;[3]Lanzhou Univ, Sch Basic Med Sci, Lanzhou, Peoples R China;[4]Univ Adelaide, Adelaide Med Sch, Adelaide, SA, Australia

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp, Sleep Med Ctr, Lanzhou 73000, Peoples R China.

年份：2021

卷号：51

期号：5

起止页码：732

外文期刊名：INTERNAL MEDICINE JOURNAL

收录：;Scopus(收录号：2-s2.0-85106953378);WOS:【SCI-EXPANDED(收录号:WOS:000655246900014)】；

基金：This study was funded by the National Science Foundation of China (81560228) and a Scientific Research Project of Gansu Health Industry (GSWSKY2016-07).The authors gratefully acknowledge and are grateful for the assistance with the recruitment, and PSG sleep assessments to the Sleep Medicine Center of Gansu Provincial Hospital and the School of Basic Medical Sciences, Lanzhou University respectively. We also thank all participants who took part in the study.

语种：英文

外文关键词：primary insomnia; 5‐ hydroxytryptamine; polymorphism

摘要：Background Primary insomnia is a worldwide problem and it has a considerable negative impact on one's physical and mental health. Studies have shown that non-synonymous Single-nucleotide polymorphisms in 5-hydroxytryptamine (serotonin or 5-HT) are related to primary insomnia. Previous studies have shown that 5-HT polymorphism (rs140700) is related to depression, and insomnia is often accompanied by depression and anxiety. The relationship between this site and primary insomnia is unknown. We speculated that this site may be related to primary insomnia, so we investigated the relationship between rs140700 and primary insomnia. Aims To explore the relationship between the 5-HT gene polymorphism rs140700 and primary insomnia. Methods In this study, we included 57 patients with primary insomnia and 54 age- and gender-matched normal controls. The subjects who belonged to the Chinese population were subjected to polysomnography for three consecutive nights. Their sleep quality was assessed, and the genotypes of the 5-hydroxytryptamine (5-HT) gene polymorphism rs140700 were determined by the flight mass spectrometry. Results The genotype distributions of the 5-HT gene polymorphism rs140700 were in Hardy-Weinberg equilibrium in both patients and controls (P > 0.05). The allele and genotype distributions of this variant were comparable between the patients and controls in all subjects and between genders (all P > 0.05). The influence of rs140700 on percentage of stage 1 (P = 0.015) change and arousal index (P = 0.028) of primary insomnia was statistically significant. The logistic multi-factor regression analysis results revealed that 5-HT gene polymorphism rs140700 was not a risk factor for primary insomnia in the Chinese population (P = 0.589). Conclusions The 5-HT gene polymorphism rs140700 may not be a susceptibility locus for primary insomnia in the Chinese population.