文献类型：期刊文献

英文题名：Comprehensive analysis of the potential pathogenesis of COVID-19 infection and liver cancer

作者：Rong, Yao[1,2,3,4];Tang, Ming-Zheng[1,2,3,4];Liu, Song-Hua[1,2];Li, Xiao-Feng[1];Cai, Hui[2,3,4,5]

第一作者：Rong, Yao

通信作者：Cai, H[1]

机构：[1]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Prov Hosp, Gen Surg Clin Med Ctr, Lanzhou 730000, Gansu, Peoples R China;[3]Gansu Prov Hosp, Key Lab Mol Diag & Precis Med Surg Oncol Gansu Pro, Lanzhou 730000, Gansu, Peoples R China;[4]Gansu Prov Hosp, NHC Key Lab Diag & Therapy Gastrointestinal Tumor, Lanzhou 730000, Gansu, Peoples R China;[5]Gansu Prov Hosp, Gen Surg Clin Med Ctr, 204 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp, Gen Surg Clin Med Ctr, 204 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China.

年份：2024

卷号：16

期号：2

起止页码：436

外文期刊名：WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY

收录：;Scopus(收录号：2-s2.0-85185497394);WOS:【SCI-EXPANDED(收录号:WOS:001181461700023)】；

基金：Supported by 2021 Central-Guided Local Science and Technology Development Fund; National Key Research and Development Program, No. 2018YFC1311506; Gansu Provincial People's Hospital Intramural Cultivation Key Project, No. 19SYPYA-1; and Lanzhou COVID-19 Prevention and Control Technology Research Project, No. 2020-XG-1.

语种：英文

外文关键词：COVID-19; Liver cancer; Differentially expressed genes; Hub genes; Pathogenesis

摘要：BACKGROUND A growing number of clinical examples suggest that coronavirus disease 2019 (COVID-19) appears to have an impact on the treatment of patients with liver cancer compared to the normal population, and the prevalence of COVID-19 is significantly higher in patients with liver cancer. However, this mechanism of action has not been clarified. AIM To investigate the disease relevance of COVID-19 in liver cancer. METHODS Gene sets for COVID-19 (GSE180226) and liver cancer (GSE87630) were obtained from the Gene Expression Omnibus database. After identifying the common differentially expressed genes (DEGs) of COVID-19 and liver cancer, functional enrichment analysis, protein-protein interaction network construction and screening and analysis of hub genes were performed. Subsequently, the validation of the differential expression of hub genes in the disease was performed and the regulatory network of transcription factors and hub genes was constructed. RESULTS Of 518 common DEGs were obtained by screening for functional analysis. Fifteen hub genes including aurora kinase B, cyclin B2, cell division cycle 20, cell division cycle associated 8, nucleolar and spindle associated protein 1, etc., were further identified from DEGs using the "cytoHubba" plugin. Functional enrichment analysis of hub genes showed that these hub genes are associated with P53 signalling pathway regulation, cell cycle and other functions, and they may serve as potential molecular markers for COVID-19 and liver cancer. Finally, we selected 10 of the hub genes for in vitro expression validation in liver cancer cells. CONCLUSION Our study reveals a common pathogenesis of liver cancer and COVID-19. These common pathways and key genes may provide new ideas for further mechanistic studies.