文献类型：期刊文献

英文题名：Comparison studies of constituents between Dangguibuxuetang and its single medicines via hyphenated chromatography and multicomponent spectral correlative chromatography

作者：Wang, YL; Liang, YZ; Hu, Y; Li, BY; Zeng, ZD; Xu, SP

通信作者：Liang, YZ[1]

机构：[1]Cent S Univ, Res Ctr Modernizat Chinese Herbal Med, Changsha 410083, Peoples R China;[2]Gansu Coll Tradit Chinese Med, Dept Pharm, Lanzhou 730000, Peoples R China;[3]Kwansei Gakuin Univ, Dept Chem, Sch Sci & Technol, Sanda 6691337, Japan;[4]Jilin Univ, Key Lab Supermol Struct & Mat, Minist Educ, Changchun 130023, Peoples R China

第一机构：Cent S Univ, Res Ctr Modernizat Chinese Herbal Med, Changsha 410083, Peoples R China

通信机构：[1]corresponding author), Cent S Univ, Res Ctr Modernizat Chinese Herbal Med, Changsha 410083, Peoples R China.

年份：2006

卷号：27

期号：2

起止页码：222

外文期刊名：CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE

收录：;EI(收录号：2006139784161);Scopus(收录号：2-s2.0-33645165053);WOS:【SCI-EXPANDED(收录号:WOS:000235414300007)】；

语种：英文

外文关键词：hyphenated chromatography; multicomponent spectral correlative chromatography; Dangguibuxuetang; single medicine; component comparison

摘要：In this study, a compound medicine of Dangguibuxuetang and its two involved single medicines of Danggui (Radix Angelica sinensis) and Huangqi (Radix Astragali) were compared for their relevant constituents after the combination of hyphenated chromatography and multicomponent spectral correlative chromatography, based on the two-dimensional spectrochromatographic fingerprints of the three medicinal objects obtained from HPLC-DAD. It was found that of twenty-one high peaks in Dangguibuxuetang, eight originate from Radix Angelica sinensis, six from Radix Astragali, and seven from both Radix Angelica sinensis and Radix Astragali. A little of other components in the investigated overlapping peaks varied. Moreover, new chemical ingredients appeared just in spectrochromatographic fingerprints of Dangguibuxuetang, and some existing in those of single medicines contrarily disappeared after the compatibility, as opposite in Radix Angelica sinensis and Radix Astragali. It suggested that there are certain interactions of the chemical ingredients in compound medicine besides their total sum effect of single medicines. This proposed approach was quite convenient and reliable to make a quick comparison and analysis of the relevant constituents in spectrochromatographyic fingerprints of the compound and single medicines, especially for the comparison of two overlapping peaks.