文献类型：期刊文献

英文题名：Current status of research on muscle wasting associated with chronic obstructive pulmonary disease

作者：Zhang, Huanhuan[1];Song, Zhangbo[4];Guo, Qi[1];Nie, Haiyi[1];Hou, Hongdou[1];Yao, Ning[1];Dai, Sichao[1];Yun, Chengcai[1];Zhuo, Qihong[1];Li, Yangyang[1];Zhang, Liying[1,2];Yong, Wenxing[3]

第一作者：张海涵

通信作者：Zhang, LY[1];Zhang, LY[2];Yong, WX[3]

机构：[1]Gansu Univ Tradit Chinese Med, 35 Dingxi East Rd, Lanzhou 730000, Peoples R China;[2]Key Lab Tradit Chinese Med Explorat & Innovat Tran, Lanzhou, Peoples R China;[3]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou 730000, Peoples R China;[4]Heze Tradit Chinese Med Hosp, Heze, Shandong, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, 35 Dingxi East Rd, Lanzhou 730000, Peoples R China;[2]corresponding author), Key Lab Tradit Chinese Med Explorat & Innovat Tran, Lanzhou, Peoples R China;[3]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou 730000, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2026

卷号：31

期号：1

外文期刊名：EUROPEAN JOURNAL OF MEDICAL RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001795932300002)】；

基金：National Natural Science Foundation of China (82160868); Scientific Research Projects in the Health and Wellness Industry of Gansu Province (GSWSKY2025-15).

语种：英文

外文关键词：Sarcopenia; Lung diseases; Chronic obstructive pulmonary disease; Myogenesis; Complication

摘要：Due to persistent airflow limitation, COPD patients frequently develop sarcopenia, creating a bidirectional worsening cycle: Diagnosis involves pulmonary function tests for COPD and consensus criteria (e.g., EWGSOP2) for sarcopenia. COPD promotes sarcopenia through chronic inflammation, protein metabolic imbalance, oxidative stress, and hypoxia, while sarcopenia impairs immune and respiratory muscle function, accelerating pulmonary decline. Pathogenesis is complex, involving signaling pathways that regulate inflammation, protein balance, muscle fiber transformation, and mitochondrial function. Contributing factors include sarcopenic obesity, malnutrition, hormonal disorders, corticosteroid use, and inactivity. Treatment focuses on smoking cessation, pharmacotherapy, nutritional support, and resistance exercise, with acupuncture showing potential. Current research is preliminary, with mechanisms unclear and no specific therapies available. Early diagnosis and personalized multidisciplinary interventions are crucial to disrupt the COPD-sarcopenia cycle, delay disease progression, and enhance physical function and quality of life. Therefore, this review summarizes how skeletal muscle metabolism participates in the pathophysiological processes of COPD and potential therapeutic agents for sarcopenia, aiming to provide beneficial recommendations for the clinical prevention and treatment of sarcopenia in COPD patients from a complex mechanistic perspective.