文献类型：期刊文献

英文题名：Pharmacological and non-pharmacological treatments for opioid-induced constipation A protocol for systematic review and network meta-analysis

作者：Zhang, Jing[1,2];Mao, Lanfang[1,2];Wang, Longde[2];Lu, Cuncun[3];Du, Xiaojuan[2];Liang, Qiankun[1];Yang, Bo[1];Wu, Hongli[1]

第一作者：张靖;张杰;张晶

通信作者：Mao, LF[1]

机构：[1]Gansu Univ Tradit Chinese Med, Lanzhou, Gansu, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Affiliated Hosp, Lanzhou, Gansu, Peoples R China;[3]Lanzhou Univ, Sch Basic Med Sci, Evidence Based Med Ctr, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Affiliated Hosp, Dept Spleen & Stomach Dis, 732 Jiayuguan West Rd, Lanzhou 730020, Gansu, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2019

卷号：98

期号：4

外文期刊名：MEDICINE

收录：;Scopus(收录号：2-s2.0-85060550001);WOS:【SCI-EXPANDED(收录号:WOS:000462296900031)】；

基金：Youth project of Gansu University of Traditional Chinese Medicine (ZQN2016-17) and Natural fund project of Science and Technology Department of Gansu Province (No. 1212RJZA081).

语种：英文

外文关键词：acupuncture; network meta-analysis; opioid-induced constipation; pharmacological treatment; systematic review

摘要：Background: Pain is very common and its management with a huge burden for patients and the healthcare system. And the network meta-analysis was designed to provide reference for the clinical practice. Methods: PubMed, EMBASE, Cochrane library, CNKI, VIP, Wan Fang, and CBM will be systematically searched their inception to November 2018. Randomized controlled trials that compared the effect of differently pharmacological or non-pharmacological treatments for opioid-induced constipation will be included. The primary outcome is the efficacy of therapeutic regimens. Risk of bias assessment of the included studies will be performed using the Cochrane risk of bias tool. A network meta-analysis will be performed using STATA 13.0 software with WinBUGS 1.4.3 software. Grading of Recommendations Assessment, Development, and Evaluation will be used to assess the overall quality of evidence. Results: This study is ongoing and will be submitted to a peer-reviewed journal for publication. Conclusion: This study will provide a comprehensive evidence on the effectiveness and safety of pharmacological and non-pharmacological treatments for opioid-induced constipation.