文献类型：期刊文献

中文题名：不同干燥方法对黄芪浓缩液的影响研究

英文题名：Effects of Different Drying Methods on the Concentrates of Astragalus membranaceus

作者：万玲娟[1];何红杰[1];李金田[1,2];冯晓莉[1,2];刘晓霞[1];魏舒畅[1,2];武晓玉[1]

第一作者：万玲娟

机构：[1]甘肃中医药大学,兰州730000;[2]甘肃省中药制药工艺工程研究中心,兰州730000

第一机构：甘肃中医药大学

年份：2024

卷号：59

期号：2

起止页码：172

中文期刊名：中国药学杂志

外文期刊名：Chinese Pharmaceutical Journal

收录：CSTPCD;;Scopus;北大核心:【北大核心2023】；CSCD:【CSCD2023_2024】；PubMed;

基金：甘肃省高等学校产业支撑引导项目资助(2019C-02);研究生创新基金项目资助(2021CX42)。

语种：中文

中文关键词：黄芪浓缩液;真空干燥;指纹图谱;层次分析法-熵权法;聚类分析

外文关键词：Astragalus membranaceus concentrate;vacuum drying;fingerprinting;AHP-entropy weight method;cluster analysis

摘要：目的考察不同干燥方法对黄芪浓缩液的影响及其变化规律,为其干燥工艺的优选和建立提供依据。方法以黄芪甲苷、毛蕊异黄酮葡萄糖苷、毛蕊异黄酮、芒柄花苷、黄芪多糖、乙醇浸出物含量以及澄明度指数、溶解性指数为评价指标,采用冷冻干燥、真空干燥、常压干燥、微波干燥对黄芪浓缩液进行干燥,以层次分析法(AHP)和熵权法联合确定各指标权重,通过综合评分、聚类分析、指纹图谱的联合使用并结合各干燥方法本身的特性,优选最佳干燥方法。结果不同干燥方法对黄芪浓缩液的影响差异较大,冷冻干燥和真空干燥综合评分最高,常压干燥和微波干燥评分较低。根据相似度评价分析可知,冷冻干燥和真空干燥样品的指纹图谱与浓缩液的指纹图谱相似度最高,2种干燥法所得样品间差异较小,结果与综合评分相似。在实验范围内,黄芪浓缩液在冷冻干燥、真空干燥条件下比较稳定。结论不同干燥方式和条件对黄芪浓缩液的影响差异较大,通过对4种干燥方法的研究,最终选取真空干燥为黄芪浓缩液最适宜的干燥方法。
OBJECTIVE To investigate the effects of different drying methods on the concentrates of Astragalus membranaceus and provide a basis for the optimization and establishment of their drying processes.METHODS The contents of Astragalus methyloside,Pistil isoflavone glucoside,Pistil isoflavone,Mangiferin,Astragalus polysaccharide,ethanol extract and the clarity index and solubility index were used as evaluation indexes to dry Astragalus concentrate by freeze-drying,vacuum drying,atmospheric pressure drying and microwave drying,and the weights of each index were jointly determined by hierarchical analysis(AHP)and entropy weighting method,and the most suitable drying method was selected by the combination of comprehensive scoring,cluster analysis,fingerprinting and other methods as well as the characteristics of each drying method itself.RESULTS The effects of different drying methods on the concentration of Astragalus membranaceus varied widely,with the highest comprehensive scores for freeze-drying and vacuum-drying and lower scores for atmospheric-pressure drying and microwave drying.According to the analysis of similarity evaluation software,the fingerprint profiles of freeze-dried and vacuum-dried samples were the most similar to those of concentrates,the differences between the samples obtained from the two drying methods were small,and the results were similar to the comprehensive scores.Within the experimental range,the concentrates of Astragalus membranaceus were more stable under freeze-drying and vacuum-drying conditions.CONCLUSION The effect of different drying methods and conditions on Astragalus concentrates varies greatly.Through the study of four drying methods,vacuum drying is finally selected as the most suitable drying method for Astragalus concentrates.