文献类型：期刊文献

中文题名：中国脑卒中流行病学和疾病负担的Meta分析

英文题名：Epidemiology and disease burden of stroke in China:a meta-analysis

作者：李亚芳[1,2,3];梁珊珊[1,2,3];王子怡[1,2,3];张发强[1,2,3];黄家艺[1,2,3];陶俊良[1,2,3];杨克虎[1,2,3];李秀霞[1,2,3];王荣[4]

第一作者：李亚芳

机构：[1]兰州大学卫生技术评估中心/兰州大学循证社会科学研究中心,兰州大学公共卫生学院,兰州730000;[2]兰州大学循证医学中心,兰州大学基础医学院,兰州730000;[3]甘肃省循证医学与临床转化重点实验室,兰州730000;[4]甘肃中医药大学附属医院脊柱外科,兰州730000

第一机构：兰州大学卫生技术评估中心/兰州大学循证社会科学研究中心,兰州大学公共卫生学院,兰州730000

年份：2025

卷号：25

期号：6

起止页码：664

中文期刊名：中国循证医学杂志

外文期刊名：Chinese Journal of Evidence-based Medicine

收录：;北大核心:【北大核心2023】；

基金：国家自然科学基金面上项目(编号:72074103)。

语种：中文

中文关键词：脑卒中;流行病学;疾病负担;系统评价;Meta分析

外文关键词：Stroke;Epidemiology;Burden of disease;Systematic review;Meta-analysis

摘要：目的系统评价我国脑卒中的发病率、死亡率和疾病负担。方法计算机检索CNKI、WanFang Data、VIP、CBM、PubMed、Embase、Web of Science和Cochrane Library数据库,搜集关于中国脑卒中流行病学和疾病负担的队列研究,检索时限均从建库至2024年6月30日。由2位研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Stata 18.0软件进行Meta分析。结果共纳入49项研究,结果显示:我国脑卒中总体发病率为430/10万[95%CI(370/10万,490/10万)];男性脑卒中发病率为510/10万[95%CI(450/10万,580/10万)];女性脑卒中发病率为370/10万[95%CI(320/10万,410/10万)]。我国脑卒中总体死亡率为220/10万[95%CI(160/10万,280/10万)];男性脑卒中死亡率为160/10万[95%CI(120/10万,190/10万)];女性脑卒中死亡率为130/10万[95%CI(100/10万,160/10万)]。我国脑卒中平均标化DALY率为2238.09/10万,男性(3510.53/10万)高于女性(2083.39/10万)。结论我国男性脑卒中风险显著高于女性,主要归因于男性较高的吸烟饮酒率、不良饮食习惯以及对健康管理的忽视。此外,不同区域间的老龄化程度差异,尤其是东部和北部地区较高的老龄化水平,也对这些地区的脑卒中发病率产生了显著影响。
Objective To systematically review the incidence,mortality and disease burden of stroke in China.Methods The CNKI,WanFang Data,VIP,CBM,PubMed,Embase,Web of Science and Cochrane Library databases were electronically searched to collect cohort studies on stroke epidemiology and disease burden from inception to June 30,2024.Two reviewers independently screened the literature,extracted data,and assessed the risk of bias of the included studies.Meta-analysis was then performed using Stata 18.0 software.Results A total of 49 studies were included,and the results showed that the overall incidence of stroke in China was 430/100000(95%CI 370/100000 to 490/100000);The incidence of stroke in men was 510/100000(95%CI 450/100000 to 580/100000);The incidence of stroke in women was 370/100000(95%CI 320/100000 to 410/100000).The overall mortality rate of stroke in China was 220/100000(95%CI 160/100000 to 280/100000);Stroke mortality in men was 160/100000(95%CI 120/100000 to 190/100000);Stroke mortality in women was 130/100000(95%CI 100/100000 to 160/100000).The average standard DALY rate of stroke in China was 2238.09/100000,and men(3510.53/100000)was higher than that of women(2083.39/100000).Conclusion The risk of stroke in men in China is significantly higher than that in women,which is mainly attributed to the higher rate of smoking and drinking alcohol,poor eating habits and the neglect of health management.Moreover,interregional differences in aging,especially the higher aging levels in the eastern and northern regions,also have a significant impact on stroke incidence in these regions.