文献类型：期刊文献

英文题名：Exploring key genes related to ferroptosis amino acid metabolism in lung adenocarcinoma based on transcriptome data

作者：Li, Wen[1,2];Wu, Ruiyue[3];Chen, Xi[3];Guo, Juanjuan[3];Jian, Shengqiang[2];Su, Fei[4];Yuan, Fangyun[4];Lu, Yongbin[5];Zhao, Da[4];Zhang, Tao[4];Hou, Xiaoming[1,4]

第一作者：李雯

通信作者：Hou, XM[1];Zhang, T[2];Hou, XM[2]

机构：[1]Gansu Univ Tradit Chinese Med, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Gen Hosp Lanzhou Petrochemical Co, Dept Oncol & Hematol, Affiliated Hosp 4, Lanzhou 730000, Gansu, Peoples R China;[3]Lanzhou Univ, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China;[4]Lanzhou Univ, Hosp 1, Dept Oncol, 1 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China;[5]Lanzhou Univ, Sch Publ Hlth, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Lanzhou Univ, Hosp 1, Dept Oncol, 1 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2026

卷号：17

期号：1

外文期刊名：DISCOVER ONCOLOGY

收录：;Scopus(收录号：2-s2.0-105051873704);WOS:【SCI-EXPANDED(收录号:WOS:001888469600002)】；

基金：This work was supported by National Natural Science Foundation of China (82260518,82560495); The Key Talent Project of the Organization Department of the Gansu Provincial Committee of the Communist Party of China(2025RCXM036); The unite Pesearch Foundation of Gansu Province (23JRRA1497,25JRRA1245); The Science and Technology Program of Gansu Province(26JRRA027, 23JRRA0928, 23JRRA1607); The youth Science and Technology Talent Innovation Project of Lanzhou City (2023-QN-14); The Scientific and Technological Development Guiding Plan Project of Lanzhou City(2020-ZD-74); The Science and Technology Plan Project in Chengguan District, Lanzhou City, Gansu Province (2021RCCX0008); The First Hospital of Lanzhou University (ldyyyn2022-88, ldyyyn2022-65 and ldyyyn2023-7).

语种：英文

外文关键词：Lung adenocarcinoma; Ferroptosis; Amino acid metabolism; GOT1; Prognostic biomarker

摘要：Lung adenocarcinoma (LUAD) is a highly aggressive cancer with limited treatment options. This study investigated key genes linking ferroptosis and amino acid metabolism in LUAD using bioinformatics and experimental validation. Analysis of TCGA and GEO datasets identified GOT1 (upregulated) and CDO1 (downregulated) as core regulators. High GOT1 expression was associated with advanced clinicopathological characteristics and poor survival (log-rank P < 0.05). Functional studies demonstrated that GOT1 knockdown suppressed LUAD cell proliferation and clonogenic growth while promoting apoptosis, and also reduced tumor growth in vivo (P < 0.001). In addition, CDO1 showed an expression pattern consistent with a potentially protective role in LUAD and was inversely correlated with GOT1 (Spearman's R = - 0.177, P < 0.001). Finally, a prognostic model incorporating GOT1 showed strong predictive accuracy (C-index = 0.705). These findings highlight the important role of GOT1 in LUAD progression and suggest that it may contribute to ferroptosis-related amino acid metabolic reprogramming, supporting its potential as a prognostic biomarker and therapeutic target.