文献类型：期刊文献

英文题名：Norcantharidin combined with diamminedichloroplatinum inhibits tumor growth and cancerometastasis of hepatic carcinoma in murine

作者：Zhang, Xiao-Ping[1];Luo, Lu-Lu[2];Liu, Yong-Qi[1];Liu, Xue-Song[1];An, Fang-Yu[1];Sun, Shao-Bo[1];Xie, Xiao-Rong[1];Geng, Guang-Qin[1];Chen, Xue-Juan[1];Li, Zhen-Dong[3]

第一作者：张小平

通信作者：Liu, YQ[1]

机构：[1]Gansu Univ Chinese Med, Inst Integrated Tradit Chinese Med & Western Med, 35 Dingxi East Rd, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Dept Nursing, Lanzhou, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Dept Med Imageol, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Inst Integrated Tradit Chinese Med & Western Med, 35 Dingxi East Rd, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2018

卷号：14

期号：12

起止页码：S1035

外文期刊名：JOURNAL OF CANCER RESEARCH AND THERAPEUTICS

收录：;Scopus(收录号：2-s2.0-85058591274);WOS:【SCI-EXPANDED(收录号:WOS:000453452300017)】；

基金：The study was supported by the talent introduction program in Gansu University of Chinese Medicine, the National Natural Science Foundation of China (Grant No. 81360345) and Natural Science Foundation of Gansu Science and Technology Department (Grant No. 1208RJZA221).

语种：英文

外文关键词：Diamminedichloroplatinum; hepatic carcinoma; norcantharidin

摘要：Aim: Norcantharidin (NCTD) has been used as a clinical antineoplastic drug in China for several years, and diamminedichloroplatinum is a valuable clinical cancer chemotherapy agent. Here, we tried to investigate the effects of NCTD plus diamminedichloroplatinum on hepatic carcinoma in murine. Materials and Methods: In vivo and in vitro investigations on anticancer effects of the two drugs were individually made. Result: In vitro, the combination of the two drugs resulted in apparent apoptosis and cell proliferation inhibitions of H22 cancer cells. Meanwhile, their coadministration in vivo produced significant suppressions of tumor growth and cancerometastasis. Further, CD31 immunohistochemistry and matrigel tube formation assay demonstrated that angiogenesis was inhibited by NCTD plus diamminedichloroplatinum in vivo and in vitro, respectively. Conclusion: Based on the findings, we concluded that NCTD plus diamminedichloroplatinum may have an additive anticancer efficacy because the two drugs work in different ways, and thus, their combination had inhibited cancer cell proliferations and tumor angiogenesis more effectively than either of the compounds alone.