文献类型：期刊文献

中文题名：中药基于TRPV1信号通路改善腹泻型肠易激综合征内脏敏感性研究进展

英文题名：Study on the Treatment of Visceral Sensitivity Based on TRPV 1 Signaling

作者：李亚静[1];刘俊宏[2];赖学倩[1];李明[1];李林蔓[1]

第一作者：李亚静

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃中医药大学附属医院,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2024

卷号：38

期号：9

起止页码：53

中文期刊名：实用中医内科杂志

外文期刊名：Journal of Practical Traditional Chinese Internal Medicine

基金：国家自然科学基金地区基金项目(81660773);甘肃省中西医结合消化病临床医学研究中心项目(21JR7RA682);甘肃省中医药管理局科研项目(GZK-2018-15)。

语种：中文

中文关键词：瞬时受体电位通道香草素亚型1信号通路;肠易激综合征;内脏敏感性;腹痛;中医药

外文关键词：TRPV1,signaling pathway;irritable bowel syndrome;visceral sensitivity;abdominal pain;traditional Chinese medicine

摘要：肠易激综合征是临床常见消化系统疾病,临床以腹痛腹泻为主要症状,其发病机制以内脏敏感性增高,肠道通透性改变等为主。内脏敏感性增高可分为中枢性和外周性。外周敏化指的是肠道、自律神经和DRG信号的异常,而中枢敏化指的是脊髓背侧神经元的敏化和大脑水平信号处理的异常。临床以外周敏化为主。通过查阅文献发现TRPV1信号通路作为治疗肠易激综合征的主要信号通路之一,瞬时受体电位通道香草素亚型1激活会改变细胞内和细胞外Ca2+的流动性,增加内脏组织和器官的敏感性,引起痛觉过敏和病理性疼痛。文章整合相关研究并进行总结,旨在为临床治疗IBS-D提供治疗研究依据,以期对中医药治疗IBS-D提供新思路。
Irritable bowel syndrome is a common clinical digestive system disease,with abdominal pain and diarrhea as the main symptom.The pathogenesis is mainly increased visceral sensitivity and intestinal permeability.Increased visceral sensitivity can be divided into central and peripheral properties.Peripheral sensitization refers to abnormal intestinal,autonomic afferents and DRG signaling,central sensitization refers to sensitization of dorsal horn neurons in the spinal cord and abnormal processing of afferent signals at the brain.Clinical external peripheral sensitization mainly.Through a large review of relevant literature,TRPV 1 signaling pathway was found as one of the main signaling pathways for the treatment of irritable bowel syndrome.After TRPV 1 is activated,Ca 2+mobility inside and outside the cells is changed,increasing the sensitivity of internal tissues and organs,and making the body produce hyperalgesia and pathological pain.This paper integrates and summarizes relevant studies at home and abroad,aiming to provide therapeutic research basis for the clinical treatment of IBS-D,in order to provide new ideas for the treatment of IBS-D in TCM.