文献类型：期刊文献

英文题名：The tendency of malignant transformation of mesenchymal stem cells in the inflammatory microenvironment, TAFs or TSCs?

作者：Luo, Yali[1,2];Liu, Yongqi[1,2];An, Fangyu[1,2];Zhang, Liying[1,2];Li, Chenghao[1,2];Zhang, Yanhui[1,2];Ren, Chunzhen[1,2]

第一作者：骆亚莉;Luo, Yali

通信作者：Liu, YQ[1]

机构：[1]Prov Level Key Lab Mol Med Major Dis & Prevent &, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Tradit Chinese Med, 35 Dingxi East Rd, Lanzhou 730000, Gansu, Peoples R China

第一机构：Prov Level Key Lab Mol Med Major Dis & Prevent &, Lanzhou 730000, Gansu, Peoples R China

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, 35 Dingxi East Rd, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2018

卷号：11

期号：3

起止页码：1490

外文期刊名：INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000429006600012)】；

基金：We sincerely thank the financial supports received from projects to help us to complete this experiment. Funded project: The national natural science foundation grants programs in China (81360588, 81760804).

语种：英文

外文关键词：MSCs; malignant transformation; TAF; TSC; inflammatory microenvironment

摘要：MSCs showed broad application prospects in clinical medicine on account of those excellent characteristics. In inflammatory tumor microenvironment, MSCs can be recruited to nearly all the inflammatory sites and the mechanisms mainly be related to inflammatory cytokines, chemokines and other factors. In the development process of tumor, they showed dual effects of promotion or inhibition and the roles are still controversial. It is not known whether the graft show abnormal differentiation and proliferation or not. Not to mention how to control them differentiate into established directions. In this regard, most of the current studies are in vitro. At present, it is still not clear that whether MSCs in the inflammatory or tumoral microenvironment will undergo malignant transformation and even form tumors or not. We think that those roles of MSCs on tumors mainly depend on the changes of the microenvironment. When the microenvironment of the stem cells is changed, the interactions between both are changed too. Those complicated interactions may stimulate some key genes of signal pathways regulating proliferation, self-renewal, differentiation and other activities of MSCs. The primary coordination between stem cells and microenvironments is out of balance. So MSCs have more chance to get malignant changes. The occurrence of inflammatory microenvironment may lead to the trend of malignant transformation of MSCs: TSCs or TAFs. In conclusion, the tendency of malignant transformation of MSCs mainly depends on the interaction (cross-talk) between stem cells and microenvironment, especially the ability of stem cell to respond to circumstance changes and the ability to maintain stemness.