文献类型：期刊文献

英文题名：ATP-P2X7R-NLRP3 Axis as a Unifying Mechanism of ATP-Induced Cell Death in Degenerative Bone and Cardiovascular Diseases

作者：Zhang, Jingjing[1,2,3];Li, Linzhu[4];Guo, Qianwen[5];Liu, Xuesong[6];Qiao, Qian[1,2,3];Ye, Xuerui[1,2,3];Ding, Hongyang[1,2,3];Liu, Yi[7];Wang, Kaikai[8];Zhang, Haoling[9];Cheng, Lu[1,2,3]

第一作者：Zhang, Jingjing

通信作者：Cheng, L[1];Cheng, L[2];Cheng, L[3];Zhang, HL[4]

机构：[1]Kunming Med Univ, Fuwai Yunnan Hosp, Affiliated Cardiovasc Hosp, Chinese Acad Med Sci, Kunming 650000, Peoples R China;[2]Yunnan Prov Cardiovasc Clin Med Ctr, Kunming 650000, Peoples R China;[3]Yunnan Prov Cardiovasc Clin Med Res Ctr, Kunming 650000, Peoples R China;[4]Gansu Univ Chinese Med, Clin Coll Tradit Chinese Med, Lanzhou 730000, Peoples R China;[5]Gansu Univ Chinese Med, Sch Hlth Management, Lanzhou 730000, Peoples R China;[6]Gansu Univ Chinese Med, Basic Med Coll, Lanzhou 730000, Peoples R China;[7]Kunming Med Univ, Afffliated Hosp 2, Dept Crit Care Med, Kunming 650101, Peoples R China;[8]Gansu Univ Chinese Med, Coll Acupuncture Moxibust & Tuina, Lanzhou 730000, Peoples R China;[9]Univ Sains Malaysia, Adv Med & Dent Inst, Dept Biomed Sci, Kepala Batas 13200, Penang, Malaysia

第一机构：Kunming Med Univ, Fuwai Yunnan Hosp, Affiliated Cardiovasc Hosp, Chinese Acad Med Sci, Kunming 650000, Peoples R China

通信机构：[1]corresponding author), Kunming Med Univ, Fuwai Yunnan Hosp, Affiliated Cardiovasc Hosp, Chinese Acad Med Sci, Kunming 650000, Peoples R China;[2]corresponding author), Yunnan Prov Cardiovasc Clin Med Ctr, Kunming 650000, Peoples R China;[3]corresponding author), Yunnan Prov Cardiovasc Clin Med Res Ctr, Kunming 650000, Peoples R China;[4]corresponding author), Univ Sains Malaysia, Adv Med & Dent Inst, Dept Biomed Sci, Kepala Batas 13200, Penang, Malaysia.

年份：2026

卷号：19

外文期刊名：JOURNAL OF INFLAMMATION RESEARCH

收录：;Scopus(收录号：2-s2.0-105032752810);WOS:【SCI-EXPANDED(收录号:WOS:001714660000001)】；

基金：Yunnan Fundamental Research Kunming Medical University Projects (No.202401AY070001-164) , and Yunnan Provincial Clinical Medicine Research Special Program (No.202405AJ310003) .

语种：英文

外文关键词：ATP-induced cell death; purinergic signaling; mitochondrial dysfunction; NLRP3 inflammasome; degenerative bone disorders; cardiovascular remodeling

摘要：Extracellular Adenosine triphosphate (ATP), acting as both an energy signal and damage-associated molecular pattern (DAMP), plays a critical role in the progression of degenerative bone diseases (DBD) and cardiovascular diseases (CVD). Through activation of purinergic receptors, particularly P2X7, ATP induces a cascade of events leading to ATP-induced cell death (AICD), characterized by calcium influx, mitochondrial dysfunction, oxidative stress, and inflammasome activation, culminating in pyroptosis, apoptosis, and ferroptosis. These processes are implicated in osteoarthritis (OA), intervertebral disc degeneration (IVDD), osteoporosis (OP), and cardiovascular conditions such as myocardial infarction and heart failure. The ATP-P2X7-NLRP3 axis emerges as a shared molecular mechanism linking these diseases, driven by energy imbalance and chronic inflammation. This review explores the molecular mechanisms of AICD in DBD and CVD, evaluates experimental and clinical evidence, and discusses potential therapeutic strategies targeting the ATP-purinergic-mitochondrial axis, offering insights into integrated treatment approaches for both disease types.