文献类型：期刊文献

英文题名：ZnO nanomaterials target mitochondrial apoptosis and mitochondrial autophagy pathways in cancer cells

作者：Li, Yuanyuan[1];Li, Jingjing[2];Lu, Yan[3];Ma, Yonghua[1,4]

第一作者：Li, Yuanyuan

通信作者：Ma, YH[1]

机构：[1]Gansu Agr Univ, Coll Vet Med, Lanzhou, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Coll Pharm, Lanzhou, Peoples R China;[3]Northwest Normal Univ, Coll Phys & Elect Engn, Lanzhou, Peoples R China;[4]Gansu Agr Univ, Coll Vet Med, Lanzhou 730000, Peoples R China

第一机构：Gansu Agr Univ, Coll Vet Med, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Gansu Agr Univ, Coll Vet Med, Lanzhou 730000, Peoples R China.

年份：2024

卷号：42

期号：1

外文期刊名：CELL BIOCHEMISTRY AND FUNCTION

收录：;Scopus(收录号：2-s2.0-85181446707);WOS:【SCI-EXPANDED(收录号:WOS:001134270900001)】；

基金：The author thanks the supervisor for their guidance on the research direction and the research platform provided by the College of Veterinary Medicine, Gansu Agricultural University. Lanzhou Science and Technology Plan Project (2022-2-112), Gansu Agricultural University (GAU-7 XKJS-2018-073, GAU-KYQD-2017RCZX-11, GAU-QDFC-2020-11), Gansu Province natural sciences fund (188JR3RA16, 21JR1RA233), National Natural Science Foundation Project (CN) (31460659).

语种：英文

外文关键词：combining anticancer drugs; mitochondrial apoptosis; mitochondrial autophagy; synthesis method; zinc oxide nanomaterials

摘要：In recent years, the application of engineering nanomaterials has significantly contributed to the development of various biomedical fields. Zinc oxide nanomaterials (ZnO NMts) have gained wide popularity due to their biocompatibility, unique physical and chemical properties, stability, and cost-effectiveness for large-scale production. They have emerged as potential materials for anticancer applications. This article provides a comprehensive review of the synthesis methods of ZnO NMts and highlights the advantages of combining ZnO NMts with anticancer drugs as a nano platform for cancer treatment. Additionally, the article briefly explains the mechanism of action of ZnO NMts in tumor cells, focusing on the mitochondrial pathways that target cell apoptosis and autophagy. It is observed that these pathways are primarily influenced by reactive oxygen species generated through oxidative stress. The article discusses the promising prospects of ZnO NMts combined with anticancer drugs in the field of cancer medicine and emphasizes the need for further in-depth research on the mitochondrial apoptosis and mitochondrial autophagy pathways. The application of engineered nanomaterials has helped promote the development of various biomedical fields in recent years. Zinc oxide nanomaterials (ZnO NMts) have been widely used in many biomedical fields and become one of the candidate materials for anticancer applications due to their biocompatibility, unique physicochemical properties, stability, and low-cost large-scale production. This article reviews the advantages of ZnO NMts nanoplatform in cancer treatment, abnormal apoptosis-the occurrence of cancer, the development of glioma, the effects of ZnO NMts in vitro and in vitro tumor cell models, as well as the mitochondrial pathway of apoptosis and autophagy. It was found that it was mainly related to reactive oxygen species produced by oxidative stress, and the proapoptotic proteins Bcl-2-related X protein (BAX), Bcl-2 antagonist/killer (BAK) and p53 indirectly or directly led to the increase of mitochondrial membrane permeability and ultimately mitochondrial apoptosis. Hypoxia inducible factor-1 alpha (HIF-1 alpha) involved HIF-1 alpha-BNIP3-LC3B pathway mediates the mitophagy pathway.