文献类型：期刊文献

英文题名：Association of Retinol and Carotenoids Content in Diet and Serum With Risk for Colorectal Cancer: A Meta-Analysis

作者：Han, Xiaoyong[1,2,3];Zhao, Rangyin[4];Zhang, Guangming[4];Jiao, Yajun[1];Wang, Yongfeng[4];Wang, Da[5];Cai, Hui[2,3,6,7]

第一作者：Han, Xiaoyong

通信作者：Cai, H[1];Cai, H[2];Cai, H[3];Cai, H[4]

机构：[1]Ning Xia Med Univ, Grad Sch, Yinchuan, Peoples R China;[2]Gansu Prov Hosp, Gen Surg Clin Med Ctr, Lanzhou, Peoples R China;[3]Gansu Prov Hosp, Key Lab Mol Diagnost & Precis Med Surg Oncol Gansu, Lanzhou, Peoples R China;[4]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou, Peoples R China;[5]Jiangsu Univ, Med Coll, Zhenjiang, Peoples R China;[6]Lanzhou Univ, Clin Coll Med 1, Lanzhou, Peoples R China;[7]Gansu Prov Hosp, NHC Key Lab Diag & Therapy Gastrointestinal Tumor, Lanzhou, Peoples R China

第一机构：Ning Xia Med Univ, Grad Sch, Yinchuan, Peoples R China

通信机构：[1]corresponding author), Gansu Prov Hosp, Gen Surg Clin Med Ctr, Lanzhou, Peoples R China;[2]corresponding author), Gansu Prov Hosp, Key Lab Mol Diagnost & Precis Med Surg Oncol Gansu, Lanzhou, Peoples R China;[3]corresponding author), Lanzhou Univ, Clin Coll Med 1, Lanzhou, Peoples R China;[4]corresponding author), Gansu Prov Hosp, NHC Key Lab Diag & Therapy Gastrointestinal Tumor, Lanzhou, Peoples R China.

年份：2022

卷号：9

外文期刊名：FRONTIERS IN NUTRITION

收录：;Scopus(收录号：2-s2.0-85134208065);WOS:【SCI-EXPANDED(收录号:WOS:000827969700001)】；

基金：This study was supported by the grants from the Central to Guide Local Scientific and Technological Development (ZYYDDFFZZJ-1), Key talent project of Gansu Province of the Organization Department of Gansu provincial Party committee (2020RCXM076), Key Laboratory of gastrointestinal cancer diagnosis and treatment of National Health Commission (2019PT320005), Gansu Provincial Youth Science and Technology Fund Program (21JR7RA642), Gansu Key Laboratory of molecular diagnosis and precision treatment of surgical tumors (18JR2RA033), Guiding plan for scientific and technological development of Lanzhou (2019-ZD-102), and Natural Science Foundation of Gansu Province (21JR11RA186).

语种：英文

外文关键词：retinol; carotenoids; colorectal cancer; risk; meta-analysis

摘要：Background: Colorectal cancer (CRC) risk is linked to serum and dietary retinol and carotenoids, according to clinical and epidemiological research. However, the findings are not consistent. As a result, we did this meta-analysis to determine the link between them. Methods: From 2000 through 2022, the PubMed, Web of Science, and Embase databases, as well as pertinent article references, were searched and filtered based on inclusion and exclusion criteria and literature quality ratings. High and low intake were used as controls, and OR (odds ratio) or RR (relative risk) and 95% confidence interval were extracted. The extracted data were plotted and analyzed using Stata12.0 software. Results: A total of 22 relevant studies were included, including 18 studies related to diet and 4 studies related to serum. For high and low intake or concentration controls, the pooled OR was as follows: beta-carotene (OR = 0.89, 95% CI: 0.78-1.03), alpha-carotene (OR = 0.87, 95% CI: 0.72-1.03), lycopene (OR = 0.93, 95% CI: 0.81-1.07), lutein/zeaxanthin (OR = 0.96, 95% CI: 0.87-1.07), beta-cryptoxanthin (OR = 0.70, 95% CI: 0.48-1.01), total carotenoids (OR = 0.97, 95% CI: 0.81-1.15), retinol (OR = 0.99, 95% CI: 0.89-1.10), serum carotenoids (OR = 0.73, 95% CI: 0.58-0.93), serum retinol (OR = 0.62, 95% CI: 0.26-1.49). Subgroup analysis was performed according to tumor type, study type and sex. Conclusion: Total carotenoid intake and Lutein/Zeaxanthin intake were not associated with CRC risk. High beta-carotene, alpha-carotene, lycopene, and beta-cryptoxanthin all tended to reduce CRC risk. Serum carotenoid concentrations were significantly inversely associated with CRC risk.