文献类型：期刊文献

英文题名：A Pharmacodynamic Evaluation of the Protective Effects of Roxadustat Against Hypoxic Injury at High Altitude

作者：Guo, Qianwen[1,2];Li, Xue[1];Li, Wenbin[1,3];Wang, Rong[1];Zhao, Anpeng[1];Wang, Zihan[1,2]

第一作者：Guo, Qianwen

通信作者：Li, WB[1]

机构：[1]PLA Joint Logist Support Force, Pharm 940th Hosp, Lanzhou, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Sch Pharm, Lanzhou, Peoples R China;[3]Chinese Peoples Liberat Army, 940th Hosp Joint Logist Support Force, Key Lab Plateau Environm Damage Control, Lanzhou 730050, Peoples R China

第一机构：PLA Joint Logist Support Force, Pharm 940th Hosp, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Chinese Peoples Liberat Army, 940th Hosp Joint Logist Support Force, Key Lab Plateau Environm Damage Control, Lanzhou 730050, Peoples R China.

年份：2023

卷号：17

起止页码：75

外文期刊名：DRUG DESIGN DEVELOPMENT AND THERAPY

收录：;Scopus(收录号：2-s2.0-85146505032);WOS:【SCI-EXPANDED(收录号:WOS:000919622200001)】；

基金：This work was supported by the National Natural Science Foundation of China (Grant No. 82173738) , the 940th hospital of PLA Joint Logistics Support Force Troop Upbringing Program (Grant No. 2021yxky005) , and the All Army Youth Upbringing Program (Grant No. 20QNPY070) .

语种：英文

外文关键词：roxadustat; high altitude; hypoxia; pharmacodynamics; erythrocyte

摘要：Purpose: To investigate roxadustat's preventive effects on hypoxia damage in the quick ascent to high altitude.Methods: The roxadustat (7.8 mg/kg, 15.6 mg/kg, and 31.2 mg/kg) and control groups of BALB/C mice were distributed at random. To evaluate roxadustat's anti-hypoxic effectiveness at the recommended dose, an atmospheric pressure closed hypoxic experiment was used. Wistar rats were randomly assigned to groups that received normal oxygen, hypoxic, acetazolamide, or roxadustat in order to evaluate the protective effects against hypoxic damage. Animal blood was obtained for arterial blood-gas analysis, inflammatory factors, and the identification of oxidative stress indicators. Animal tissues were removed for pathological investigation.Results: In each group, the mice's survival time was noticeably extended compared to the normal oxygen group. The medium dose had the best time extension rate at 19.05%. Blood SatO2 and PaO2 were significantly higher in the roxadustat group compared to the hypoxic group. Erythrocyte content, hemoglobin content, and hematocrit were also significantly higher. Plasma levels of IL-6, TNF-alpha, and IFN-gamma were also significantly lower in the roxadustat group. Roxadustat can also improve the level of oxidative stress in the tissues of hypoxic rats. According to the results of HE staining, roxadustat could greatly lessen the harm done to rat heart, brain, lung, liver, and kidney tissue as a result of hypoxia.Conclusion: Roxadustat can greatly reduce inflammation, oxidative stress, and tissue damage brought on by hypoxia, showing that it can enhance the to adapt to altitude exposure.