文献类型：期刊文献

英文题名：Changing Cinnamaldehyde Skeleton Achieves Antibacterial Nanoswitch

作者：Zhao, Xiaoying[1];Miao, Ruoyan[1];Xu, Tianze[2];Du, Xiaolong[2];Zhang, Xueyan[3];Zhao, Wanyu[1];Xie, Huidong[1];Zhang, Liang[1];He, Jianzheng[3];Ma, Zhenhui[4];Liu, Hu[1,5]

第一作者：Zhao, Xiaoying

通信作者：Zhang, L[1];Liu, H[1];He, JZ[2];Ma, ZH[3];Liu, H[4]

机构：[1]Xian Univ Architecture & Technol, Sch Chem & Chem Engn, Xian 710055, Peoples R China;[2]Nanjing Univ, Nanjing Drum Tower Hosp, Affiliated Hosp, Dept Vasc Surg,Med Sch, Nanjing 210008, Peoples R China;[3]Gansu Univ Chinese Med, Res & Expt Ctr, Lanzhou 730000, Peoples R China;[4]Beijing Technol & Business Univ, Dept Phys, Beijing 100048, Peoples R China;[5]Chinese Acad Sci, Qinghai Inst Salt Lakes, Key Lab Green & High End Utilizat Salt Lake Resour, Xining 810008, Peoples R China

第一机构：Xian Univ Architecture & Technol, Sch Chem & Chem Engn, Xian 710055, Peoples R China

通信机构：[1]corresponding author), Xian Univ Architecture & Technol, Sch Chem & Chem Engn, Xian 710055, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Res & Expt Ctr, Lanzhou 730000, Peoples R China;[3]corresponding author), Beijing Technol & Business Univ, Dept Phys, Beijing 100048, Peoples R China;[4]corresponding author), Chinese Acad Sci, Qinghai Inst Salt Lakes, Key Lab Green & High End Utilizat Salt Lake Resour, Xining 810008, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

卷号：16

期号：14

起止页码：17838

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20241515873184);Scopus(收录号：2-s2.0-85189554477);WOS:【SCI-EXPANDED(收录号:WOS:001195044900001)】；

基金：This work was supported by the National Natural Science Foundation of China (Grant Nos. 52271189, 82100517, and 82104562) and the National Key Research and Development Program of China (Grant No. 2022YFB3505900). We thank Miss Fang Song at Instrument Analysis Center of Xi'an University of Architecture and Technology for their assistance with FESEM and TEM measurements.

语种：英文

外文关键词：cinnamaldehyde derivatives; organic nanosheets; electron cloud density; antibacterial nanoswitch; antibacterial mechanism

摘要：Changeable substituent groups of organic molecules can provide an opportunity to clarify the antibacterial mechanism of organic molecules by tuning the electron cloud density of their skeleton. However, understanding the antibacterial mechanism of organic molecules is challenging. Herein, we reported a molecular view strategy for clarifying the antibacterial switch mechanism by tuning electron cloud density of cinnamaldehyde molecule skeleton. The cinnamaldehyde and its derivatives were self-assembled into nanosheets with excellent water solubility, respectively. The experimental results show that alpha-bromocinnamaldehyde (BCA) nanosheets exhibits unprecedented antibacterial activity, but there is no antibacterial activity for alpha-methylcinnamaldehyde nanosheets. Therefore, the BCA nanosheets and alpha-methylcinnamaldehyde nanosheets achieve an antibacterial switch. Theoretical calculations further confirmed that the electron-withdrawing substituent of the bromine atom leads to a lower electron cloud density of the aldehyde group than that of the electron-donor substituent of the methyl group at the alpha-position of the cinnamaldehyde skeleton, which is a key point in elucidating the antimicrobial switch mechanism. The excellent biocompatibility of BCA nanosheets was confirmed by CCK-8. The mouse wound infection model, H&E staining, and the crawling ability of drosophila larvae show that as-prepared BCA nanosheets are safe and promising for wound healing. This study provides a new strategy for the synthesis of low-cost organic nanomaterials with good biocompatibility. It is expected to expand the application of natural organic small molecule materials in antimicrobial agents.