文献类型：期刊文献

英文题名：Mitochondrial quality control and its role in osteoporosis

作者：Yan, Chunlu[1,2];Shi, Yao[3];Yuan, Lingqing[3];Lv, Donghui[1];Sun, Bai[1];Wang, Jiayu[1];Liu, Xiyan[4];An, Fangyu[5]

第一作者：颜春鲁

通信作者：Liu, XY[1];An, FY[2]

机构：[1]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Res Ctr Tradit Chinese Med Gansu, Lanzhou, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Sch Basic Med, Lanzhou, Gansu, Peoples R China;[4]Northwestern Univ, Internal Med, Xian, Shanxi, Peoples R China;[5]Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Northwestern Univ, Internal Med, Xian, Shanxi, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2023

卷号：14

外文期刊名：FRONTIERS IN ENDOCRINOLOGY

收录：;Scopus(收录号：2-s2.0-85147922269);WOS:【SCI-EXPANDED(收录号:WOS:000931098300001)】；

基金：Funding This article was funded by the grants from the National Natural Science Foundation of China (82060872), Natural Science Program in Gansu Province (21JR11RA138) and the Project in Science and Technique Plans of Lanzhou City (2022-3-22).

语种：英文

外文关键词：osteoporosis; mitochondrial biogenesis; mitochondrial autophagy; targeted therapy; mitochondrial fusion and fission

摘要：Mitochondria are important organelles that provide cellular energy and play a vital role in cell differentiation and apoptosis. Osteoporosis is a chronic metabolic bone disease mainly caused by an imbalance in osteoblast and osteoclast activity. Under physiological conditions, mitochondria regulate the balance between osteogenesis and osteoclast activity and maintain bone homeostasis. Under pathological conditions, mitochondrial dysfunction alters this balance; this disruption is important in the pathogenesis of osteoporosis. Because of the role of mitochondrial dysfunction in osteoporosis, mitochondrial function can be targeted therapeutically in osteoporosis-related diseases. This article reviews different aspects of the pathological mechanism of mitochondrial dysfunction in osteoporosis, including mitochondrial fusion and fission, mitochondrial biogenesis, and mitophagy, and highlights targeted therapy of mitochondria in osteoporosis (diabetes induced osteoporosis and postmenopausal osteoporosis) to provide novel targets and prevention strategies for the prevention and treatment of osteoporosis and other chronic bone diseases.