文献类型：期刊文献

中文题名：磁共振扩散峰度成像在抑郁症患者脑白质微结构中的研究进展

英文题名：Research progress of magnetic resonance diffusion kurtosis imaging on the microstructure of white matter in patients with major depressive disorder

作者：买丽[1];李孝忠[2];伍东洋[1];李玉宁[1]

第一作者：买丽

机构：[1]甘肃中医药大学第一临床医学院,兰州730000;[2]甘肃中医药大学附属医院放射科,兰州730000

第一机构：甘肃中医药大学临床医学院

年份：2026

卷号：17

期号：1

起止页码：134

中文期刊名：磁共振成像

外文期刊名：Chinese Journal of Magnetic Resonance Imaging

收录：;北大核心:【北大核心2023】；

语种：中文

中文关键词：抑郁症;扩散峰度成像;磁共振成像;脑白质;脑微观结构

外文关键词：major depressive disorder;diffusion kurtosis imaging;magnetic resonance imaging;white matter;brain microstructure

摘要：抑郁症是一种以持续性情绪低落、兴趣丧失和快感缺失为核心特征的重性精神疾病,并伴随认知、行为、生理功能的异常,严重时可能出现自杀观念或行为。全球患病率约5%,导致沉重的社会经济负担。扩散峰度成像是一种基于水分子的非高斯扩散技术,能够表现出水分子扩散受限的高度不均质性,能更好地研究复杂纤维区域的白质属性,从而获取神经纤维的形态参数。目前抑郁症的研究大多聚集在扩散张量成像或脑灰质方面,难以充分概括当前研究进展。本文重点研究了扩散峰度成像的各项参数值与抑郁症脑白质变化及临床症状的相关性,并提出了今后的研究方向,旨在为抑郁症的早期诊断、疗效评估及预后预测提供影像学依据。
Depression is a severe mental disorder characterized by persistent low mood,loss of interest and anhedonia,accompanied by abnormal cognitive,behavioral and physiological functions.In severe cases,suicidal thoughts or behaviors may occur.The global prevalence rate is approximately 5%,resulting in a heavy socio-economic burden.Diffusion kurtosis imaging is a non-Gaussian diffusion technique based on water molecules,which can demonstrate the high heterogeneity of water molecule diffusion limitations and better study the white matter properties of complex fibrous regions,thereby obtaining the morphological parameters of nerve fibers.At present,most research on depression focuses on diffusion tensor imaging or brain gray matter,making it difficult to fully summarize the current research progress.This article mainly studies the correlation between the parameter values of diffusion kurtosis imaging and the changes in white matter of the brain and clinical symptoms in depression,and proposes future research directions,aimed at providing imaging evidence for the early diagnosis,disease monitoring and optimization of treatment plans of depression.