文献类型：期刊文献

中文题名：肠道菌群与外泌体及其协同作用对骨稳态影响的研究进展

英文题名：Research Progress of Intestinal Flora and Exosomes and Their Synergistic Effects on Bone Homeostasis

作者：齐鑫[1];刘建军[2];张晓刚[2];陈欣[2];赵希云[2];王志鹏[2];陈一新[1];李锦锋[1];刘硕[1]

第一作者：齐鑫

机构：[1]甘肃中医药大学,兰州730000;[2]甘肃中医药大学附属医院,兰州730000

第一机构：甘肃中医药大学

年份：2023

卷号：45

期号：1

起止页码：103

中文期刊名：中国细胞生物学学报

外文期刊名：Chinese Journal of Cell Biology

收录：CSTPCD;;CSCD:【CSCD_E2023_2024】；

基金：张晓刚全国名老中医药专家传承工作室建设项目(批准号:国中医药人教函[2022]75号);兰州市人才创新创业项目(批准号:2020-RC-64);甘肃省教育厅高等学校创新基金(批准号:2022B-109);2020年甘肃省青年科技基金(批准号:20JRTORA345);兰州市城关区科技计划(批准号:2020-2-2-7);2021年卫生健康行业科研项目(批准号:GSWSKJ-2021-009)资助的课题。

语种：中文

中文关键词：肠道菌群;外泌体;骨稳态;成骨细胞;破骨细胞

外文关键词：intestinal flora;exosomes;bone homeostasis;osteoblasts;osteoclasts

摘要：骨稳态是基于成骨细胞与破骨细胞代谢的动态平衡状态,对骨质疏松症、骨关节炎及股骨头坏死等骨科代谢性疾病的进程至关重要。随着细胞生物分子工程的发展,肠道菌群或外泌体的研究已成为预防或治疗骨代谢相关性疾病的热点,在免疫调节、炎症反应、细胞凋亡、骨代谢及内环境稳态方面的研究颇多。目前在肠道菌群和外泌体协同作用对疾病的调控方面的研究较少,以及对于骨代谢相关性疾病机制的探索方面更是较为有限。笔者通过查阅相关文献,认为肠道菌群与外泌体存在相关性,并且此二者在骨科疾病的治疗方面可能具有很高的研究价值。因此,该文就肠道菌群、外泌体及其协同作用对骨稳态影响的最新研究进展作一综述,以期为临床治疗骨相关性疾病提供新的思路与依据。
Bone homeostasis is based on the dynamic balance of osteoblast and osteoclast metabolism,which is crucial to the progress of metabolic diseases in orthopedics such as osteoporosis,osteoarthritis and femoral head necrosis.With the development of cellular biomolecular engineering,the study of intestinal flora or exosomes has become a hot spot in the prevention or treatment of bone metabolism-related diseases.There are many studies on immune regulation,inflammatory response,apoptosis,bone metabolism and homeostasis.At present,there are few studies on the regulation of diseases based on the synergistic effect of intestinal flora and exosomes,and the exploration of bone metabolism related diseases is limited.Through consulting relevant literature,the authors believe that intestinal flora is correlated with exosomes,and may have high research value in the treatment of orthopedic diseases.Therefore,this paper reviews the latest research progress on the effects of intestinal flora,exosomes and their synergistic effects on bone homeostasis,in order to provide new ideas and basis for clinical treatment of bonerelated diseases.