文献类型：期刊文献

英文题名：The effects of mesenchymal stem cells-derived exosomes in rheumatoid arthritis: a review

作者：Qi, W.[1];Li, F.[1];Wang, G.[2];Yan, Y.[3];Tian, J.[2];Wang, T.[1,2];Wang, Z.[1];Zhang, Y.[1]

第一作者：Qi, W.

通信作者：Wang, G[1]

机构：[1]Gansu Univ Tradit Chinese Med, Lanzhou, Peoples R China;[2]Affiliated Hosp Gansu Univ Tradit Chinese Med, 732 Jianyugan Rd, Lanzhou 730020, Gansu, Peoples R China;[3]Gansu Univ Tradit Chinese Med, Affiliated Hosp 4, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Affiliated Hosp Gansu Univ Tradit Chinese Med, 732 Jianyugan Rd, Lanzhou 730020, Gansu, Peoples R China.

年份：2024

卷号：42

期号：7

起止页码：1495

外文期刊名：CLINICAL AND EXPERIMENTAL RHEUMATOLOGY

收录：;Scopus(收录号：2-s2.0-85199152817);WOS:【SCI-EXPANDED(收录号:WOS:001273862500023)】；

基金：Funding: this research was supported by the National Natural Science Foundation of China (81960832, 8182150236) and the Excellent Doctoral Program of Gansu University of Traditional Chinese Medicine (2022-0905-JCC-0112) .

语种：英文

外文关键词：rheumatoid arthritis; mesenchymal stem cells; exosomes; pathological mechanisms

摘要：Rheumatoid arthritis (RA) is a most common chronic joint disease belonging to inflammatory autoimmune disease. The pathology of the disease is characterised by the infiltration and proliferation of fibroblast like synoviocytes (FLSs) and the destruction of the bone and cartilage matrix, which leads to joint dysfunction and even deformity. In recent years, an increasing number of studies have shown that MSCs have immunosuppressive properties and have been demonstrated in a variety of disease. Exosomes serve as carriers that mediate intercellular material transfer and information exchange and contain a variety of biologically active components such as proteins, lipids, and nucleic acids. Mesenchymal stem cellderived exosomes (MSCs-Exos) play a regulatory role by carrying bioactive substances from the parental cells. Exos-derived from MSCs of different origins can modulate several pathological processes, such as immune inflammatory response, improvement of bone metabolis. In this research, we reviewed the current major pathogenesis of RA and explored the important role of MSCsExos in this disease. To be more precise, we summarised the effects of different MSCs-Exos on the pathomechanisms of RA, with a view to providing guidance and reference for future studies.