文献类型：期刊文献

英文题名：Protective effect of Potentilla anserina polysaccharide on cadmium-induced nephrotoxicity in vitro and in vivo

作者：Shen, Rong[1];Liu, Disheng[2];Hou, Chenchen[1];Liu, Di[1];Zhao, Lixia[1,4];Cheng, Ju[1];Wang, Degui[3];Bai, Decheng[1]

第一作者：Shen, Rong

通信作者：Bai, DC[1];Wang, DG[2]

机构：[1]Lanzhou Univ, Sch Basic Med Sci, Inst Integrated Tradit Chinese & Western Med, Lanzhou 730000, Gansu, Peoples R China;[2]Lanzhou Univ, Hosp 1, Dept Urol Surg, Lanzhou 730000, Gansu, Peoples R China;[3]Lanzhou Univ, Sch Basic Med Sci, Dept Anat & Histol, Lanzhou 730000, Gansu, Peoples R China;[4]Gansu Univ Chinese Med, Sch Nursing, Lanzhou 730000, Gansu, Peoples R China

第一机构：Lanzhou Univ, Sch Basic Med Sci, Inst Integrated Tradit Chinese & Western Med, Lanzhou 730000, Gansu, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Sch Basic Med Sci, Inst Integrated Tradit Chinese & Western Med, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Lanzhou Univ, Sch Basic Med Sci, Dept Anat & Histol, Lanzhou 730000, Gansu, Peoples R China.

年份：2017

卷号：8

期号：10

起止页码：3636

外文期刊名：FOOD & FUNCTION

收录：;EI(收录号：20174304296342);Scopus(收录号：2-s2.0-85031770822);WOS:【SCI-EXPANDED(收录号:WOS:000413199800020)】；

基金：This study was supported by Fundamental Research Funds for the Central Universities (No. lzujbky-2016-61) and the National Natural Science Foundation of China (Grant No. 81472541 to D.W.). We thank Professor Xiaoyun Zhang for his help in the preparation of Potentilla anserina polysaccharide.

语种：英文

外文关键词：Cadmium - Cell death - Mammals

摘要：The aim of this research was to investigate the antioxidant and anti-apoptotic activities of Potentilla anserina polysaccharide (PAP) on kidney damage induced by cadmium (Cd) in vitro and in vivo. PAP has been suggested to have anti-oxidation, anti-apoptosis, immunoregulation, antimicrobial, antitussive, and expectorant abilities. In this study, PAP was extracted and the major components of PAP were analyzed. It was shown that PAP pretreatment remarkably improved redox homeostasis, both in human embryonic kidney 293 (HEK293) cells and in BALB/c mice. Administration of PAP attenuated the mitochondrial dysfunction, degeneration, and fibrosis of kidney induced by Cd. Furthermore, PAP exhibited anti-apoptotic activity, which involved regulating both the mitochondria-mediated intrinsic apoptotic pathway and the death receptor-initiated extrinsic pathway. These results suggest that PAP is a potential therapeutic agent for Cd-induced nephrotoxicity.