文献类型：期刊文献

中文题名：铁死亡对糖尿病及其并发症影响及中药干预进展

英文题名：Effect of Ferroptosis on Diabetes Mellitus and Its Complications and Intervention of Chinese Medicine:A Review

作者：张钦媛[1];金智生[1];姜晓雪[1];陈彦旭[1];张博玲[1];伏瑶琴[1]

第一作者：张钦媛

机构：[1]甘肃中医药大学,兰州730000

第一机构：甘肃中医药大学

年份：2024

卷号：30

期号：6

起止页码：280

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;Scopus;北大核心:【北大核心2023】；CSCD:【CSCD2023_2024】；

基金：国家自然科学基金项目(82060854)。

语种：中文

中文关键词：铁死亡;糖尿病;糖尿病并发症;中药;机制

外文关键词：ferroptosis;diabetes mellitus;diabetic complications;Chinese medicine;mechanism

摘要：糖尿病是由于胰岛素分泌绝对或相对不足引起的以长期高血糖症为特征的一种代谢性疾病。随着糖尿病病情的进展,罹患糖尿病肾病、糖尿病心肌病、糖尿病合并非酒精性脂肪肝病等并发症的人数不断扩增,给患者及社会都带来沉重负担。铁死亡是近年来广受关注的一种细胞新型程序性死亡方式,主要是指在铁离子过载下,脂质过氧化物过度累积导致的细胞死亡。现已有多项研究发现糖尿病及其并发症中存在铁死亡现象,通过抑制铁死亡可极大减缓糖尿病及其并发症的发生和进展。中药是我国独具特色的瑰宝,具有多通路、多方向的优势且价廉、不良反应小的特色,已被广泛用于糖尿病及其并发症的治疗并取得较好疗效,为广大患者带来福音。从中药调节铁死亡的角度入手可能是未来治疗糖尿病及其并发症的新方向。该文简要阐述铁死亡机制,探讨铁死亡与糖尿病及其并发症之间联系,总结中药干预铁死亡治疗糖尿病及其并发症的研究现状,并提出建议,以期为中药治疗糖尿病及其并发症的深入研究提供参考依据。
Diabetes mellitus is a metabolic disease characterized by chronic hyperglycemia caused by absolute or relative insufficiency of insulin secretion.As the disease progresses,patients begin to suffer from diabetic nephropathy,diabetic cardiomyopathy,non-alcoholic fatty liver disease or other complications,which increase the burden on the patients.Moreover,the number of patients is increasing,which brings a heavy burden to the society.Ferroptosis is a new type of programmed cell death which has attracted wide attention in recent years.It refers to the cell death caused by the excessive accumulation of lipid peroxide under the overload of iron ions.Studies have discovered that ferroptosis exists in diabetes mellitus and its complications.Inhibiting ferroptosis can greatly slow down the occurrence and progression of diabetes mellitus and its complications.Chinese medicine,the unique medical treasure in China,acts in a multi-pathway,multi-target manner and is praised for the cheap price,low toxicity,and mild side effects.It has been widely used in the treatment of diabetes mellitus and its complications and has demonstrated definite therapeutic effects,bringing the good news for the majority of patients.The regulation of ferroptosis by Chinese medicine may be a new direction for the treatment of diabetes mellitus and its complications in the future.This paper briefly describes the mechanism of ferroptosis,explores the relationship of ferroptosis with diabetes mellitus and its complications,summarizes the research status of Chinese medicine interventions,and puts forward suggestions,aiming to provide a reference for further research on the treatment of diabetes mellitus and its complications with Chinese medicine.