文献类型：期刊文献

中文题名：线粒体自噬在糖尿病心肌病中的作用及机制研究

英文题名：Research on role and mechanism of mitophagy in diabetic cardiomyopathy

作者：杨杰[1];欧小鹏[1];张倩[1];陈永清[2]

第一作者：杨杰

机构：[1]甘肃中医药大学第一临床医学院,甘肃省兰州市730000;[2]甘肃省中心医院心内科

第一机构：甘肃中医药大学临床医学院

年份：2025

卷号：23

期号：8

起止页码：704

中文期刊名：中国心血管病研究

外文期刊名：Chinese Journal of Cardiovascular Research

基金：甘肃省自然科学基金项目(23JRRA1377);兰州市科技计划项目(2022-5-84)。

语种：中文

中文关键词：线粒体自噬;糖尿病心肌病;作用机制;药物治疗

外文关键词：Mitochondrial autophagy;Diabetic cardiomyopathy;Mechanism of action;Pharmacotherapy

摘要：糖尿病心肌病(DCM)是糖尿病的严重并发症,显著增加了糖尿病患者发生心力衰竭和死亡的风险。近年研究表明,线粒体自噬通过清除心肌细胞内受损的线粒体,可恢复线粒体稳态、减轻氧化应激并改善DCM。本文深入探讨其分子调控机制,包括PINK1/Parkin、FUNDC1、AMPK/mTOR等线粒体自噬通路,进一步分析钠-葡萄糖协同转运蛋白2抑制剂、胰高血糖素样肽-1受体激动剂和双胍类药物通过调控线粒体自噬改善DCM的潜在机制,以期为DCM的防治提供新思路和理论依据。
Diabetic cardiomyopathy(DCM)is a serious complication of diabetes mellitus that significantly increases the risk of heart failure and death in diabetic patients.Recent studies have shown that mitochondrial autophagy restores mitochondrial homeostasis,attenuates oxidative stress,and ameliorates DCM by removing damaged mitochondria from cardiomyocytes.This article provides an in-depth discussion of the molecular regulatory mechanisms,including mitochondrial autophagy pathways such as PINK1/Parkin,FUNDC1 and AMPK/mTOR,and further analyzes the role of sodium-glucose cotransporter protein 2 inhibitors,glucagon like peptide-1 receptor agonists and biguanides by regulating mitochondrial autophagy to improve the potential mechanism of DCM,in order to provide new ideas and theoretical basis for the prevention and treatment of DCM.