文献类型：期刊文献

英文题名：Pharmacological action of Angelica sinensis polysaccharides: a review

作者：Ren, Chunzhen[1,2,3];Luo, Yali[1];Li, Xiaojuan[4];Ma, Like[5];Wang, Chunling[1,2,3];Zhi, Xiaodong[5,6];Zhao, Xinke[2,3,5];Li, Yingdong[1,2,3]

第一作者：Ren, Chunzhen;任春贞

通信作者：Li, YD[1];Zhao, XK[2];Li, YD[2];Zhao, XK[3];Li, YD[3];Zhao, XK[4]

机构：[1]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou, Peoples R China;[2]Gansu Prov Key Lab Chinese Med Prevent & Treatment, Lanzhou, Peoples R China;[3]Natl Hlth Commiss Peoples Republ China, Key Specialized Cardiovasc Lab Natl Adm Tradit Chi, Key Specialized Cardiovasc Lab, Key Clin Specialty, Lanzhou, Peoples R China;[4]Jiangsu Med Coll, Sch Tradit Chinese Med, Yancheng, Peoples R China;[5]Gansu Univ Chinese Med, Sch Clin Med 1, Lanzhou, Peoples R China;[6]Gansu Univ Chinese Med, Cardiovasc Clin Med Ctr, Affiliated Hosp, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou, Peoples R China;[2]corresponding author), Gansu Prov Key Lab Chinese Med Prevent & Treatment, Lanzhou, Peoples R China;[3]corresponding author), Natl Hlth Commiss Peoples Republ China, Key Specialized Cardiovasc Lab Natl Adm Tradit Chi, Key Specialized Cardiovasc Lab, Key Clin Specialty, Lanzhou, Peoples R China;[4]corresponding author), Gansu Univ Chinese Med, Sch Clin Med 1, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：15

外文期刊名：FRONTIERS IN PHARMACOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001406288300001)】；

基金：The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by the 2021 Gansu Jiaoyu Jiebang Guashuai Project (No. 2021 jyjbgs-03), Gansu Province Traditional Chinese Medicine Prevention and Treatment of Major Diseases Special Project (No. GZKZD-2018-02), Gansu Province Major Science and Technology Special Project (No.20ZD7FA002), 2022 Gansu Province Longyuan Youth Innovation and Entrepreneurship Talent Project, 2022 Gansu Province natural sciences fund (22JR11RA128) and National Natural Science Foundation of China (NO. 82260869), National Administration of Traditional Chinese Medicine Youth Qihuang Scholars Support Project. 2021 "Double First-Class" Scientific Research Key Project (No. GSSYLXM-05-ZXYJH-11), Gansu Provincial Youth Science and Technology Fund (23JRRA1217) and National Natural Science Foundation of China (NO. 82360926), 2024 Gansu Province Outstanding Doctoral Project (24JRRA569).

语种：英文

外文关键词：ASP; chemical structure; improving anemia; liver protection; antitumour; immunomodulation

摘要：Angelica sinensis, a traditional Chinese herbal medicine and food, which has a long history of clinical application, is used to improve health conditions and treat various diseases. Angelica sinensis polysaccharides (ASP), the main active component of this traditional Chinese medicine, have multicomponent, multitarget characteristics and very broad pharmacological activities. They play important roles in the treatment of several diseases. In addition, the effect is significant, which may provide a more comprehensive database and theoretical support for applying ASP in the treatment of disease and could be considered a promising candidate for preventing disease. This review summarizes the research progress on the extraction, chemical structure, pharmacological effects, and mechanisms of ASP and its derivatives by reviewing relevant national and international literature and provides comprehensive information and a reliable basis for the exploration of new treatment strategies involving botanical drugs for disease therapy. Literature information was obtained from scientific ethnobotany and ethnomedicine databases (up to September 2024), mainly from the PubMed, Web of Science, and CNKI databases. The literature has explored the extraction, purification, structure, and pharmacological effects of Angelica sinensis polysaccharides. The search keywords for such work included "Angelica sinensis" or "Angelica sinensis polysaccharides," and "pharmacological effects," "extraction" and "structure." Multiple studies have shown that ASP has important pharmacological effects, such as antitumor, anemia-improving, anti-inflammatory, antioxidative, immunomodulatory, hepatoprotective, antifibrotic, hypoglycemic, antiradiation, and antiviral effects, the mechanisms of which appear to involve the regulation of inflammation, oxidative stress, and profibrotic signaling pathways. As a natural polysaccharide, ASP has potential applications as a drug. However, further research should be undertaken to clarify the unconfirmed regulatory mechanisms, conduct standard clinical trials, and evaluate the possible side effects. This review establishes a theoretical foundation for future studies on the structure, mechanism, and clinical use of ASP.