文献类型：期刊文献

英文题名：Registered clinical trials on addiction: a cross-sectional study on ClinicalTrials.gov

作者：Liu, Guina[1];Chen, Lingmin[2,3,4];Yang, Yi[5];Zhang, Yonggang[3,6,7];Luo, Shanxia[8]

第一作者：Liu, Guina

通信作者：Zhang, YG[1];Zhang, YG[2];Zhang, YG[3];Luo, SX[4]

机构：[1]Sichuan Univ, West China Sch Med, Chengdu, Peoples R China;[2]Sichuan Univ, West China Hosp, Dept Anesthesiol, Chengdu, Peoples R China;[3]Sichuan Univ, West China Hosp, Natl Clin Res Ctr Geriatr, Chengdu, Peoples R China;[4]Chinese Acad Med Sci, Res Units West China 2018RU012, Chengdu, Peoples R China;[5]Gansu Univ Tradit Chinese Med, Dept Clin Med, Lanzhou, Peoples R China;[6]Sichuan Univ, West China Hosp, Dept Period Press, Chengdu, Peoples R China;[7]Sichuan Univ, West China Hosp, Chinese Evidence Based Med Ctr, Chengdu, Peoples R China;[8]Sichuan Univ, West China Hosp, Dept Mental Hlth Ctr, Chengdu, Peoples R China

第一机构：Sichuan Univ, West China Sch Med, Chengdu, Peoples R China

通信机构：[1]corresponding author), Sichuan Univ, West China Hosp, Natl Clin Res Ctr Geriatr, Chengdu, Peoples R China;[2]corresponding author), Sichuan Univ, West China Hosp, Dept Period Press, Chengdu, Peoples R China;[3]corresponding author), Sichuan Univ, West China Hosp, Chinese Evidence Based Med Ctr, Chengdu, Peoples R China;[4]corresponding author), Sichuan Univ, West China Hosp, Dept Mental Hlth Ctr, Chengdu, Peoples R China.

年份：2022

卷号：40

期号：3

起止页码：394

外文期刊名：JOURNAL OF ADDICTIVE DISEASES

收录：;Scopus(收录号：2-s2.0-85127968452);WOS:【SSCI(收录号:WOS:000774963300001)】；

基金：The study was partly supported by China Postdoctoral Science Foundation (No: 2021M692274) and The Postdoctor Research Project of Sichuan University (No.2021SCU12001).

语种：英文

外文关键词：Addiction; ClinicalTrials; gov; Results; Funding source; Design

摘要：Objective Clinical trials drive the development of medicine. However, little is known about the current status of clinical trials on addiction. This study aimed to provide a comprehensive analysis of registered addiction-related trials from ClinicalTrials.gov. Methods We examined all addiction-related trials registered on ClinicalTrials.gov up to March 23, 2020. Statistical analysis was performed by using SPSS 25.0, and a two-sided p < .05 was considered statistically significant. Results 370 eligible trials were identified. Over half of trials were completed, while only 13.8% of trials reported results. Sample sizes varied a lot with a median number of 84 per trial. Universities were the primary sponsor for 164 (44.3%) trials, followed by hospitals (96, 26.0%). Compared to trials without results, more trials with results were sponsored by universities (62.7% vs. 41.4%, p = .003), and conducted in United States/Canada (90.2% vs. 48.3%, p < .001). Most interventional trials were randomized with a parallel assignment, and 56.3% were blinded. Thirty one (41.3%) observational trials were cohort studies and 12 (16.0%) were case-only studies. Interventional trials were more likely to be funded by the US Government, while more observational trials were supported by industries. Trials funded by the US Government were more likely to be completed than those funded by other sources (p = .009). Conclusion Most registered trials on ClinicalTrials.gov about addiction were interventional trials with purpose for treatment. Most interventional trials were randomized, parallel, and masked. Our analysis highlighted the need for improvement in completing study results on the ClinicalTrials.gov.