文献类型：期刊文献

中文题名：lncRNA作为ceRNA调控糖尿病心肌病的研究进展

英文题名：Progress in role of lncRNA as ceRNA in regulation of diabetic cardiomyopathy

作者：刘学霖[1];董建婷[2];王瑞麟[1];张奇[1];王国印[1];张倩[1];张月梅[1];陈永清[2]

第一作者：刘学霖

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃省中心医院心内科,甘肃兰州730070

第一机构：甘肃中医药大学

年份：2024

卷号：40

期号：10

起止页码：1969

中文期刊名：中国病理生理杂志

外文期刊名：Chinese Journal of Pathophysiology

收录：CSTPCD;;Scopus;北大核心:【北大核心2023】；CSCD:【CSCD2023_2024】；

基金：甘肃省自然科学基金资助项目(No.23JRRA1377);兰州市科技计划项目(No.2022-5-84)。

语种：中文

中文关键词：糖尿病心肌病;长链非编码RNA;竞争性内源RNA;铁死亡;细胞焦亡

外文关键词：diabetic cardiomyopathy;long noncoding RNA;competitive endogenous RNA;ferroptosis;pyroptosis

摘要：糖尿病心肌病(DCM)是由糖尿病引起的一种独特的心肌疾病,可增加心力衰竭和死亡的风险,是全球糖尿病患者死亡的主要原因之一。虽然有关DCM发病机制的研究已取得较大进展,但尚未完全阐明。许多研究表明,长链非编码RNA(lncRNA)可作为竞争性内源RNA(ceRNA)与靶微小RNA(miRNA)分子相互作用,参与基因表达的调控,进而影响DCM的发生发展过程。本文就lncRNA及其生物学功能和ceRNA假说进行概述,并着重综述了lncRNA作为ceRNA调控DCM发生发展的作用。
Diabetic cardiomyopathy(DCM)is a unique myocardial disease caused by diabetes mellitus,which can increase the risk of heart failure and death,and is one of the main causes of death of diabetes mellitus patients worldwide.Although the research on the pathogenesis of DCM has made great progress,it has not yet been fully clarified.Many studies have shown that long noncoding RNAs(lncRNAs)can interact with microRNAs(miRNAs)as competitive endogenous RNAs(ceRNAs),participate in the regulation of gene expression,and then affect the development of DCM.This article gives an overview of lncRNAs and its biological functions as well as ceRNA hypothesis,and focuses on the role of lncRNAs as ceRNAs in regulating the occurrence and development of DCM.