文献类型：期刊文献

英文题名：Electroacupuncture remodels gut microbiota and metabolites in mice with perioperative neurocognitive impairment

作者：Tang, Lu[1,2,3];Zhang, Xiaojia[1,2,3];Zhang, Binsen[1,2,3];Chen, Tianren[1];Du, Zhongying[1,2,3];Song, Wenjing[4];Chen, Wenqiang[1];Wang, Chunai[5,6]

第一作者：唐莉;Tang, Lu

通信作者：Wang, CA[1]

机构：[1]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou 730030, Peoples R China;[2]Key Lab Gansu Prov Prescript Min & Innovat Transla, Lanzhou 730030, Peoples R China;[3]Gansu Prov Tradit Chinese Med New Prod Creat Engn, Lanzhou 730030, Peoples R China;[4]Chongqing Med Univ, Clin Coll 5, Chongqing 400015, Peoples R China;[5]Gansu Prov Hosp Tradit Chinese Med, Lanzhou 730050, Peoples R China;[6]Clin Med Res Ctr Integrated Chinese & Western Med, Lanzhou 730050, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp Tradit Chinese Med, Lanzhou 730050, Peoples R China.

年份：2024

卷号：194

外文期刊名：EXPERIMENTAL GERONTOLOGY

收录：;Scopus(收录号：2-s2.0-85198021999);WOS:【SCI-EXPANDED(收录号:WOS:001345504800001)】；

基金：National Natural Science Foundation of China, Grant/Award Number: 82260973; Gansu Provincial Key Research and Development Program-Social Development Foundation, Grant/Award Number: 20YF3FA020; Lanzhou Municipal Science and Technology, Grant/Award Number: 2022-3-31.

语种：英文

外文关键词：Electroacupuncture; Neuroinflammation; Perioperative neurocognitive disorder; Gut microbiota; Microbiome-gut-brain axis

摘要：Gut microbiota and metabolites are considered key factors in the pathogenesis of perioperative neurocognitive disorders (PND), and the brain-gut axis may be a promising target for PND treatment. Electroacupuncture has been shown to improve a wide range of neurological disorders and to restore function to the gastrointestinal tract. Thus, we hypothesized whether electroacupuncture could remodel gut microbiota and neuroinflammation induced by anesthesia/surgery. First, we observed electroacupuncture at acupoints GV20, LI4 and PC6 significantly improved memory in behavioral tests. Next, we found electroacupuncture decreased the levels of inflammatory factors (NSE, S-100(3, IL-6, etc.) in the hippocampus, indicating that nerve inflammation was blocked by electroacupuncture. Furthermore, via 16S rRNA sequence analysis and LC-MS analysis, the gut microbiota and its metabolites were appropriately restored after electroacupuncture treatment. Additionally, we further confirmed the restorative effect of electroacupuncture on PND by fecal transplantation. In conclusion, the role of electroacupuncture in improving cognitive function and protecting neurons may be related to the modulation of gut microbiota and their metabolite dysregulation, thereby inhibiting neuroinflammation in PND mice.