文献类型：期刊文献

中文题名：甲基转移酶样蛋白家族的分子作用机制及在胃癌中的研究进展

英文题名：Molecular mechanism of methyltransferase-like protein family:Relationship with gastric cancer

作者：王婧[1];王文安[1];张安[1];刘宏斌[2]

第一作者：王婧

机构：[1]甘肃中医药大学,甘肃省兰州市730000;[2]解放军联勤保障部队第九四〇医院普外科,甘肃省兰州市730000

第一机构：甘肃中医药大学

年份：2020

卷号：28

期号：11

起止页码：428

中文期刊名：世界华人消化杂志

外文期刊名：World Chinese Journal of Digestology

收录：Scopus

基金：国家科技部、财政部惠民计划资助项目,No.2012GS620101;甘肃省自然科学基金资助项目,No.1506RJZA309;甘肃省科技重大专项资助项目,No.2011GS04390;甘肃中医药大学研究生创新基金资助项目,No.2019CX29.

语种：中文

中文关键词：甲基转移酶样蛋白;胃癌;METTL3;METTL9;METTL16

外文关键词：Methyltransferase-like proteins;Gastric cancer;METTL3;METTL9;METTL16

摘要：甲基转移酶样蛋白(methyltransferase-like proteins,METTL)是一个大蛋白家族的一部分,其特征是存在s-腺苷甲硫氨酸(s-adenosylmethionine,SAM)的结合域,SAM是甲基化反应的共同底物.尽管这个蛋白家族的成员被显示或预测为RNA、DNA或蛋白质的甲基转移酶,但大多数甲基转移酶的特征仍然很差,识别这些潜在酶起作用的复合物有助于了解它们的功能和底物特异性.METTL蛋白家族与胃癌(gastric cancer,GC)的发生发展有密切作用,明确其与GC的关系与GC的诊断治疗及预后有着十分重要的作用.本研究是对METTL蛋白家族的作用机制及与GC的关系一次系统和全面的综述,以期为进一步研究这些潜在的新型甲基转移酶和GC的诊治提供重要的资源.
Methyltransferase-like proteins(METTL)are part of a large protein family,which is characterized by the presence of an S-adenosylmethionine(SAM;a common substrate for methylation reactions)binding domain.Although members of this protein family have been shown or predicted as methyltransferases of RNA,DNA,or proteins,most methyltransferases are still poorly characterized.Identifying the complexes where these potential enzymes work can help to understand their function and substrate specificity.The METTL protein family is closely related to the occurrence and development of gastric cancer(GC),and its relationship with GC is of great importance in the diagnosis,treatment,and prognosis of GC.Here we give a systematic and comprehensive review of the mechanism of METTL protein family and its relationship with GC,with an aim to provide important resources for further research on these potential new methyltransferases and the diagnosis and treatment of GC.