文献类型：期刊文献

英文题名：A randomized controlled study for Yuanhu Zhitong dropping pills in the treatment of knee osteoarthritis

作者：Gu, Yubiao[1];Huang, Jin[1];Guo, Honggang[2];Song, Xuewen[2];Li, Jianguo[1];Shi, Yanlong[2];Xie, Xingwen[3,4]

第一作者：Gu, Yubiao

通信作者：Guo, HG[1];Xie, XW[2]

机构：[1]Gansu Prov Hosp TCM, Lanzhou, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Lanzhou 730000, Gansu, Peoples R China;[3]Northwest Minzu Univ, Affiliated Hosp, Dept Orthopaed, Lanzhou, Gansu, Peoples R China;[4]Gansu Second Prov Peoples Hosp, Dept Orthopaed, Lanzhou, Gansu, Peoples R China

第一机构：Gansu Prov Hosp TCM, Lanzhou, Gansu, Peoples R China

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), 1 West Hezheng St, Lanzhou 730000, Peoples R China.|[10735]甘肃中医药大学;

年份：2020

卷号：99

期号：24

起止页码：E20666

外文期刊名：MEDICINE

收录：;Scopus(收录号：2-s2.0-85086621355);WOS:【SCI-EXPANDED(收录号:WOS:000549881200065)】；

基金：This work was funded by the National Natural Science Foundation of China (grant no: 81860864, Xingwen Xie).

语种：英文

外文关键词：protocol; Yuanhu Zhitong dropping pills; Knee osteoarthritis

摘要：Background: Knee osteoarthritis (KOA) is a common chronic disorder of knee and the leading cause of pain in the elderly with an overall prevalence of 50% in people over 60 years of age. This disease is an important factor affecting the quality of life of middle-aged and elderly people, and its main symptom is knee joint pain. Due to the pain, the knee joint activity function is limited, bringing great pain to patients, affecting their quality of life, effective prevention, and treatment of KOA is a modern medical problem. Methods: The 60 patients who met the inclusion criteria were randomly divided into the treatment group and the control group. In this study, single center, randomized control and equivalent clinical trial were used for treatment. The treatment group received Yuanhu Zhitong dropping pills within 4 weeks, and the control group received diclofenac sodium sustained-release capsule treatment within 4 weeks. The main measures were visual analogue scale (VAS), WOMAC osteoarthritis index score and gastrointestinal symptoms rating scale (GSRS).Secondary measures included biochemical markers and adverse reactions during treatment. Result: The results of this trial will be published on the website of China Clinical Trial Registration Center (http://www.chictr.org.cn/searchprojen.aspx) and in peer-reviewed journals or academic conferences. Conclusions: This study is to assess the efficacy and safety of Yuanhu Zhitong dropping pills for knee osteoarthritis (KOA).