文献类型：期刊文献

英文题名：The antioxidant effects of hedysarum polybotrys polysaccharide in extending lifespan and ameliorating aging-related diseases in Drosophila melanogaster

作者：Yang, Shipei[1,2,3];Xiu, Minghui[4,5];Li, Xu[4];Shi, Yan[1,2,3];Wang, Shuwei[4];Wan, Shengfang[3];Han, Shuzhen[1,2,3];Yang, Dan[1,2,3];Liu, Yongqi[1,2,3,5];He, Jianzheng[1,2,3,5]

第一作者：Yang, Shipei

通信作者：Liu, YQ[1];He, JZ[1];Liu, YQ[2];He, JZ[2]

机构：[1]Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis, Lanzhou 730000, Peoples R China;[2]Gansu Univ Chinese Med, Prevent & Treatment Tradit Chinese Med Res Gansu C, Lanzhou 730000, Peoples R China;[3]Gansu Univ Chinese Med, Coll Basic Med, Lanzhou 730000, Peoples R China;[4]Gansu Univ Chinese Med, Coll Publ Hlth, Lanzhou 730000, Peoples R China;[5]Minist Educ, Key Lab Dunhuang Med, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis, Lanzhou 730000, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Prevent & Treatment Tradit Chinese Med Res Gansu C, Lanzhou 730000, Peoples R China.|[10735]甘肃中医药大学;

年份：2023

卷号：241

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：;EI(收录号：20240815602626);Scopus(收录号：2-s2.0-85154064888);WOS:【SCI-EXPANDED(收录号:WOS:000998929300001)】；

基金：National Natural Science Foundation of China (No. 81960793), Gansu Planning Projects on Science and Technology (No. 20JR10RA332), Research and Innovation Fund from Gansu University of Chinese Medicine (Nos. KCZD2018-2; No. 2021KCZD-2), Gansu Provincial High Education Industry Suppory Plan Project (No. YDZX20206200002673).

语种：英文

外文关键词：Hedysarum polybotrys polysaccharide; Anti-aging; Intestinal homeostasis; Sleep disturbances; Alzheimer's disease; Drosophila melanogaster

摘要：Hedysarum polybotrys polysaccharide (HPS) is one of the main active ingredients of Hedysarum with many healthbeneficial properties, including antioxidant property, immunomodulatory, anti-inflammatory, and anti-tumor. However, the effect of HPS on anti-aging is still unclear. This study was to explore the protective function of HPS on aging and age-related diseases using Drosophila melanogaster. The results demonstrated that HPS supplementation promoted hatchability and prolonged lifespan by enhancing the antioxidative capacity. Administraction of HPS ameliorated age-related symptoms such as imbalanced intestinal homeostasis, sleep disturbances, and beta-amyloid (A beta) induced Alzheimer's disease (AD) in flies, but did not modulate neurobehavioral deficits in the AD model of tauopathy and the Parkinson's disease (PD) model of Pink1 mutation. Overall, this study reveals that HPS has strong potential in the prevention of aging and age-related diseases, and provided a new candidate for the development of anti-aging drugs.