文献类型：期刊文献

中文题名：胃肠保护策略预防唑来膦酸输注相关胃肠道不良反应的应用效果

英文题名：Application effect of gastrointestinal protection strategy in preventing Zoledronic Acid infusion-related gastrointestinal adverse reactions

作者：苟爱芳[1];王晓敏[1];张娜文[1]

第一作者：苟爱芳

机构：[1]甘肃中医药大学第三附属医院、白银市第一人民医院内分泌科,甘肃白银730900

第一机构：甘肃中医药大学第二附属医院

年份：2026

卷号：16

期号：7

起止页码：59

中文期刊名：医药前沿

外文期刊名：Journal of Frontiers of Medicine

语种：中文

中文关键词：唑来膦酸;胃肠保护策略;静脉滴注;药物不良反应;肌酐清除率;电解质水平

外文关键词：Zoledronic Acid;Gastrointestinal protection strategy;Intravenous drip;Adverse drug reaction;Creatinine clearance rate;Electrolyte level

摘要：目的探讨胃肠保护策略预防唑来膦酸输注相关胃肠道不良反应的临床价值。方法选取2020年6月—2023年6月于白银市第一人民医院接受唑来膦酸输注治疗的65例患者。按照随机数字表法分为试验组(n=33)和对照组(n=32)。试验组于唑来膦酸输注前后给予抗酸药、胃黏膜保护剂等胃肠保护药物,对照组患者未给予胃肠保护干预。比较两组胃肠道不良反应发生情况、严重程度、不良反应缓解时间及血清电解质水平、肝肾功能指标。结果试验组胃肠道不良反应总发生率低于对照组,不良反应缓解时间短于对照组(P<0.05)。两组均未出现重度不良反应,但试验组轻中度不良反应占比低于对照组(P<0.05)。两组血清钾、钠、氯离子水平的组间效应、时间效应及交互效应比较,差异均有统计学意义(P<0.05),其中试验组输注后各电解质水平下降幅度小于对照组。两组丙氨酸转氨酶(alanine aminotransferase,ALT)、天冬氨酸转氨酶(aspartate aminotransferase,AST)及肌酐清除率(creatinine clearance rate,Ccr)水平的时间效应比较,差异有统计学意义(P<0.05);组间效应、交互效应比较,差异无统计学意义(P>0.05)。结论胃肠保护策略能够有效减轻唑来膦酸输注相关的胃肠道不良反应。建议将其作为唑来膦酸输注的常规辅助措施,尤其适用于高龄、营养不良或有胃肠病史的高危患者,可以提升治疗安全性及患者依从性。
Objective To explore the clinical value of gastrointestinal protection strategy in preventing Zoledronic Acid infusion-related gastrointestinal adverse reactions.Methods A total of 65 patients who received Zoledronic Acid infusion in the First People's Hospital of Baiyin from June 2020 to June 2023 were selected.According to the random number table method,they were divided into experimental group(n=33)and control group(n=32).The experimental group was given gastrointestinal protective drugs such as antacids and gastric mucosal protective agents before and after Zoledronic Acid infusion,while the control group was not given gastrointestinal protective intervention.The incidence and severity of gastrointestinal adverse reactions,remission time of adverse reactions,serum electrolyte levels,liver and kidney function indexes were compared between the two groups.Results The total incidence of gastrointestinal adverse reactions in the experimental group was lower than that in the control group,and the remission time of adverse reactions was shorter than that in the control group(P<0.05).There were no severe adverse reactions in both groups,but the proportion of mild to moderate adverse reactions in the experimental group was lower than that in the control group(P<0.05).There were significant differences in the intergroup effect,time effect and interaction effect of serum potassium,sodium and chloride levels between the two groups(P<0.05),and the decrease of electrolyte levels in the experimental group after infusion was less than that in the control group.There were significant differences in the time effects of alanine aminotransferase,aspartate aminotransferase and creatinine clearance rate levels between the two groups(P<0.05).There was no significant difference in inter-group effect and interaction effect(P>0.05).Conclusions Gastrointestinal protection strategy can effectively reduce Zoledronic Acid infusion-related gastrointestinal adverse reactions.It is recommended to use it as a routine adjuvant measure for zoledronic acid infusion,especially for high-risk patients with advanced age,malnutrition or gastrointestinal history,which can improve treatment safety and patient compliance.