文献类型：期刊文献

中文题名：中医药干预TGF-β信号通路治疗肝癌的研究进展

英文题名：Treatment of Liver Cancer by Intervening TGF-βSignaling Pathway with Traditional Chinese Medicine:A Review

作者：程豪[1];郭浩浩[2];孙俊[1,3];薛娟[3];计春燕[3];李诗旖[1];丁毓雪[1];岳华强[1]

第一作者：程豪

机构：[1]湖北中医药大学第一临床学院,武汉430065;[2]甘肃中医药大学,兰州730000;[3]湖北省中西医结合医院,武汉430015

第一机构：湖北中医药大学第一临床学院,武汉430065

年份：2026

卷号：32

期号：8

起止页码：318

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：;北大核心:【北大核心2023】；

基金：湖北省中医药管理局中医药科研项目青年人才项目(ZY2025Q017);湖北省时珍工程人才项目(省级中医药优秀青年人才)(鄂卫函[2024]256号);湖北省中西医结合医院“杏林人才工程”院级科研重点项目(H2023Z005);鄂州市科技计划项目(EZ01-007-20230067)。

语种：中文

中文关键词：肝癌;转化生长因子-β(TGF-β);信号通路;中医药;研究进展

外文关键词：liver cancer;transforming growth factor-β(TGF-β);signaling pathway;traditional Chinese medicine;research progress

摘要：肝癌是消化系统最常见的恶性肿瘤之一,且在全球新发恶性肿瘤中排名第6位。转化生长因子-β(TGF-β)调控着细胞的分化、增殖、凋亡等多种生理病理机制,在肿瘤发展过程中有着独特的抑癌、促癌双重作用。近年来,随着对肝癌的机制的不断探索,发现该通路的抑癌-促癌作用的转换在肝癌的发展中起着关键作用。中医药(TCM)以其多成分、多靶点、多途径的综合调节作用,为肝癌的分类和诊治提供了独特的视角。该文总结了TGF-β信号通路的抑癌机制包括促进癌细胞周期停滞、凋亡、自噬等,促癌机制包括促进癌细胞增殖、侵袭转移、免疫抑制、血管生成等。梳理了干预该通路的中医复方包括健脾化瘀方、扶阳保元方、益脾养肝方、扶正解毒方、黄芪丹参配伍方、鳖甲煎丸、大黄?虫丸、清香散;单味中药主要包括水田七、石斛、皂荚、剑叶龙血树;中药活性成分主要集中在黄酮类、生物碱类、苷类、酚类、萜类、多糖类及其他类化合物,同时总结了中医药调控该通路抑制肝癌的机制主要包括促进肝癌细胞凋亡、阻滞细胞周期,抑制肝癌细胞增殖、迁移、侵袭、血管生成、免疫逃逸等。以期充分发挥中医药的优势,精准调控TGF-β信号,从而发挥积极的抗肿瘤效应,为肝癌的精准靶向治疗开辟新的方向,为中医药在肝癌治疗中的应用提供科学依据和新策略。
Liver cancer is one of the most common malignant tumors in the digestive system and ranks sixth among newly diagnosed malignant tumors worldwide.Transforming growth factor-β(TGF-β)regulates cell differentiation,proliferation,apoptosis,and other physiological and pathological mechanisms and exerts cancer-suppressive and pro-cancerous dual effects in the process of tumor development.In recent years,with the continuous exploration of the mechanism of liver cancer,it has been found that the conversion of the cancer-suppressive effect into a pro-cancerous effect of this pathway plays a key role in the development of liver cancer.Traditional Chinese medicine(TCM)provides a unique perspective for the classification,diagnosis,and treatment of liver cancer with its comprehensive regulatory effects of multi-components,multi-targets,and multi-pathways.This paper summarized that the cancer-suppressive mechanisms of the TGF-βsignaling pathway included promoting cancer cell cycle arrest,apoptosis,autophagy,et al,while the pro-cancerous mechanisms included promoting cancer cell proliferation,invasion and metastasis,immunosuppression,angiogenesis,et al.The TCM compounds intervening this pathway were sorted out,including Jianpi Huayu compound,Fuyang Baoyuan compound,Yipi Yanggan compound,Fuzheng Jiedu compound,compound Astragalus and Salvia,Biejia Jianwan,Dahuang Zhechong pill,and Qingxiang powder.The single TCMs mainly included Schizocapsa plantaginea,Dendrobii Caulis,Gleditsia sinensis,and Dracaena cochinchinensis.The active ingredients of TCM are mainly concentrated on flavonoids,alkaloids,glycosides,phenolics,terpenoids,polysaccharides,and other kinds of compounds.At the same time,it summarized that the liver cancer inhibition mechanism of TCM by regulating this pathway mainly included promoting apoptosis of liver cancer cells,blocking the cell cycle,and inhibiting liver cancer cell proliferation,migration,invasion,angiogenesis,immune escape,etc.The mechanism aims to give full play to the advantages of TCM and precisely regulate the TGF-βsignal,thereby exerting positive anti-tumor effects,opening up a new direction for the precise targeted treatment of liver cancer,and providing a scientific basis and a new strategy for the application of TCM in the treatment of liver cancer.