文献类型：期刊文献

英文题名：Individual morphological brain networks, systemic inflammation, and neurocognitive alterations in type 2 diabetes

作者：He, Yangqing[1];Tan, Jian[1];Chen, Miao[3];Zhao, Yiwei[1];Yang, Chen[1,2];Zhang, Huiyan[2,4];Tian, Jing[2];Huang, Gang[2];Zhao, Ziyang[3];Yao, Zhijun[3];Zhao, Lianping[2]

第一作者：He, Yangqing

通信作者：Zhao, LP[1];Yao, ZJ[2]

机构：[1]Gansu Univ Chinese Med, Gansu Prov Hosp, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Prov Hosp, Dept Radiol, 204 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China;[3]Lanzhou Univ, Sch Informat Sci & Engn, Gansu Prov Key Lab Wearable Comp, 222 Tianshui South Rd, Lanzhou 730000, Gansu, Peoples R China;[4]Ningxia Med Univ, Sch Clin Med, Yinchuan 750000, Ningxia, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Radiol, 204 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Lanzhou Univ, Sch Informat Sci & Engn, Gansu Prov Key Lab Wearable Comp, 222 Tianshui South Rd, Lanzhou 730000, Gansu, Peoples R China.

年份：2026

卷号：240

外文期刊名：BRAIN RESEARCH BULLETIN

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001758548800001)】；

基金：This project supported by the National Natural Science Foundation of China (No.82360343); the Natural Science Foundation of Gansu Province, China (No.25JRRA296); the Key Research and Development Program of Gansu Province, China (No.23YFFA0048); the Gansu Provincial Health Commission Scientific Research Project (No. GSWSQN2024-03); the Gansu Traditional Chinese Medicine Management Scientific Research Project (No.GZKP-2020-36); the Foundation of Gansu Provincial Hospital (Nos.2024KYQDJ-A-34, 24GSSYB-15); Gansu University of Traditional Chinese Medicine Postgraduate Innovation and Entrepreneurship Fund (No.2026CXZX-929) .

语种：英文

外文关键词：Diabetes Mellitus; Type 2; Morphological similarity network; Systemic inflammation; Graph theory; Cognition

摘要：Background: Type 2 diabetes mellitus (T2DM) is closely associated with chronic low-grade inflammation and brain impairment, but how systemic inflammation affects brain morphological networks remains unclear. This study aimed to investigate the topological organization of individual-level morphological similarity networks (MSNs) in T2DM and its relationship with systemic inflammation and neuropsychological manifestations. Methods: This study comprised two distinct cohorts. Cohort 1 included 92 T2DM patients and 63 demographically matched healthy controls (HCs); all underwent MRI and neuropsychological assessments. Individual MSNs were constructed using cortical thickness similarity, and graph-theoretical analysis was applied. Cohort 2 included 40 T2DM and 40 well-matched HCs with plasma inflammatory cytokines measured. An overlapping subset (n = 39) further investigated the relationship between cytokines and topological metrics. Results: Both groups showed small-world properties in MSNs without global differences. At the nodal level, T2DM patients exhibited decreased degree centrality in the left superior frontal gyrus (SFG) and increased degree centrality/nodal efficiency in the right cingulate gyrus (CG). The ventral attention network (VAN) had higher betweenness centrality, which negatively correlated with anxiety scores. T2DM patients showed elevated pro-inflammatory cytokines (e.g., IL-6, IL-8, TNF-alpha), and IL-4 levels positively correlated with depression severity. Conclusion: T2DM is associated with distinct alterations in the topological organization of individual morphological brain networks, where the left SFG may be a vulnerable node linked to disease progression and right CG/ VAN changes may reflect compensation. Systemic inflammation, particularly IL-4, may contribute to affective symptoms, providing new network neuroscience insights into T2DM-related brain impairment.