文献类型：期刊文献

英文题名：Rauvomines A and B, Two Monoterpenoid Indole Alkaloids from Rauvolfia vomitoria

作者：Zeng, Jun[1];Zhang, Dong-Bo[1];Zhou, Pan-Pan[1];Zhang, Qi-Li[2];Zhao, Lei[2];Chen, Jian-Jun[1];Gao, Kun[1]

第一作者：Zeng, Jun

通信作者：Chen, JJ[1];Gao, K[1]

机构：[1]Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Lanzhou 730000, Gansu, Peoples R China

第一机构：Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China.

年份：2017

卷号：19

期号：15

起止页码：3998

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000407307900014)】；

基金：This work was supported by the National Basic Research Programs (973) of China (2014CB138703) and the National Natural Science Foundation of China (31470421).

语种：英文

摘要：Two unusual normonoterpenoid indole alkaloids rauvomine A (1) and rauvomine B (2), together with two known compounds peraksine (3) and alstoyunine A (4), were isolated from the aerial parts of Rauvolfia vomitoria. The structures with absolute configurations of 1 and 2 were elucidated by spectroscopic analysis, single-crystal X-ray diffraction, and electronic circular dichroism (ECD) calculations. Compound 2 is a novel C-18 normonoterpenoid indole alkaloid with a substituted cyclopropane ring that forms an unusual 6/5/6/6/3/5 hexcyclic rearranged ring system. The plausible biogenetic pathways of 1 and 2 were proposed. Compound 2 exhibited significant anti-inflammatory activity.