文献类型：期刊文献

中文题名：中药有效成分调节线粒体保护骨关节炎软骨的研究进展

英文题名：Research progress on active ingredients of traditional Chinese medicine regulating mitochondrion to protect osteoarthritis cartilage

作者：杨波[1];周明旺[2];吉星[2];李盛华[2];肖振[1];王玉[1];胡星荣[1];苏耀辉[1];徐斌[1];王雷[1]

第一作者：杨波

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃省中医院,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2021

卷号：52

期号：7

起止页码：2117

中文期刊名：中草药

外文期刊名：Chinese Traditional and Herbal Drugs

收录：CSTPCD;;Scopus;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：全国中医学术流派传承工作室第二轮建设项目(国中医人教函[2019]62号);中医药传承与创新“百千万”人才工程(岐黄工程)岐黄学者;甘肃省科技计划项目(18JR2FA009)。

语种：中文

中文关键词：中药有效成分;黄酮类;多酚类;生物碱类;皂苷类;骨关节炎;软骨;线粒体

外文关键词：active ingredients of traditional Chinese medicine;flavonoids;polyphenols;alkaloids;saponins;osteoarthritis;cartilage;mitochondria

摘要：关节软骨退变在骨关节炎发病之初便出现,继而影响关节其他组织出现病理改变,关节软骨常被作为骨关节炎病理机制和药物治疗机制研究的组织之一。关节软骨退变与线粒体形态结构和功能障碍相关,所以在预防软骨退变中保护线粒体的形态和功能成为一个新的研究方向。中药在骨关节炎治疗中有着悠久的历史,针对中药有效成分能调节线粒体,进而延缓关节软骨退变的作用机制已开展了相关研究。将中药有效成分(黄酮类、多酚类、生物碱类、皂苷类等)调节线粒体延缓关节软骨退变的分子机制关系进行综述,为骨关节炎关节软骨退变的防治提出新的目标。
Articular cartilage degeneration occurs at the beginning of the onset of osteoarthritis and then affects the pathological changes of other joint tissues. It is often regarded as one of the tissues in the study of pathological mechanism and the mechanism of drug therapy of osteoarthritis. Articular cartilage degeneration is related to mitochondrial morphological structure and dysfunction, therefore protecting mitochondrial morphology and function has become a new research direction. Traditional Chinese medicine(TCM) has a long history in the treatment of osteoarthritis. Relevant studies have been carried out on mechanism of the effective components of TCM that can protect mitochondria and delay the degeneration of articular cartilage. In this paper, the molecular mechanism of effective components of TCM(flavonoids, polyphenols, alkaloids, saponins, etc.) is well stated to protect mitochondria from degeneration of articular cartilage, and a new target is proposed for the prevention and treatment of osteoarthritis articular cartilage degeneration.