文献类型：期刊文献

英文题名：Advances in astrocytic calcium signaling research

作者：Chen, Yuzhu[1];Ye, Yejun[2];Jia, Joyce[1];Long, Binhao[2];Dou, Tingting[2];Yan, Xingke[1,2]

第一作者：Chen, Yuzhu

通信作者：Yan, XK[1];Yan, XK[2]

机构：[1]Qinghai Univ, Sch Med, Dept Tradit Chinese Med, Xining, Peoples R China;[2]Gansu Univ Chinese Med, Coll Acupuncture & Tuina, Lanzhou, Gansu, Peoples R China

第一机构：Qinghai Univ, Sch Med, Dept Tradit Chinese Med, Xining, Peoples R China

通信机构：[1]corresponding author), Qinghai Univ, Sch Med, Dept Tradit Chinese Med, Xining, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Coll Acupuncture & Tuina, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：19

外文期刊名：FRONTIERS IN CELLULAR NEUROSCIENCE

收录：;Scopus(收录号：2-s2.0-105024483867);WOS:【SCI-EXPANDED(收录号:WOS:001634262700001)】；

基金：The author(s) declare financial support was received for the research and/or publication of this article. This work was supported by the 2023 Gansu Province Joint Scientific Research Fund, General Program (grant no. 23JRRA1522), the 2024 Traditional Chinese Medicine First-level Discipline "Qihuang Talent" Mentor Special Fund (grant no. ZYXKBD-202409), the 2023 Gansu University of Chinese Medicine Science and Innovation Fund (Grant No. 2023KCYB-2), the 2025 Gansu University of Chinese Medicine Graduate "Innovation and Entrepreneurship" Fund (grant no. 2025CXCY-002), and the 2025 Gansu Province University Teachers' Innovation Fund (grant no. 2025A-115).

语种：英文

外文关键词：astrocyte calcium signaling; review; astrocyte; calcium; calcium signaling

摘要：Astrocytes are the most abundant glial cells in the central nervous system. They detect neuronal activity through Ca2+ signals and thereby regulate synaptic plasticity, integrate neuronal information, and maintain extracellular homeostasis. Growing evidence indicates that aberrant astrocytic Ca2+ signaling is an important pathological factor in the onset and progression of many neurological disorders. In this review, we systematically summarize the sources, classifications, detection methods, and functional significance of astrocyte Ca2+ signaling, with the aim of improving understanding of astrocyte function and providing new perspectives and rationale for therapeutic strategies targeting related diseases.