文献类型：期刊文献

中文题名：炎症在放射性脑损伤中的作用研究状况

英文题名：Research status on mechanisms of inflammation in radiation-induced brain injury

作者：刘秀珠[1,2,3];武兵兵[3];王燕如[1,2];李佳蔚[1,2];李程豪[1,2];李玲[1,2];王思宇[1,2];周啸天[1];刘永琦[1,2]

第一作者：刘秀珠

机构：[1]甘肃中医药大学甘肃省高校重大疾病分子医学与中医药防治研究重点实验室,甘肃兰州730050;[2]甘肃中医药大学敦煌医学与转化省部共建教育部重点实验室,甘肃兰州730050;[3]甘肃中医药大学中西医结合临床学院,甘肃兰州730050

第一机构：甘肃中医药大学科研实验中心（甘肃省中医药标准化技术委员会秘书处）

年份：2022

卷号：38

期号：9

起止页码：1007

中文期刊名：中国临床药理学杂志

外文期刊名：The Chinese Journal of Clinical Pharmacology

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：国家自然科学基金资助项目(81960869);教育厅高等学校产业支撑计划基金资助项目(2020C-15);科技厅创新基地与人才计划基金资助项目(20JR10RA332);甘肃中医药大学研究生创新基金资助项目(2021CX27);甘肃中医药大学中西医结合基础学科科研培育基金资助项目(2020-1)。

语种：中文

中文关键词：放射性脑损伤;神经炎症;炎症细胞;炎性因子

外文关键词：radiation-induced brain injury;neuroinflammation;inflammatory cells;inflammatory factors

摘要：放射性脑损伤(RBI)是原发性或继发性头颈部肿瘤放疗后严重的并发症,损害了放疗后患者的长期健康,增加了这些患者的死亡率。颅脑放疗能引起大脑的长期和慢性炎症反应,持续的炎症反应导致神经元功能障碍和细胞死亡。神经胶质细胞活化、小胶质细胞激活及炎症因子的产生等都可以促进神经炎症反应,造成神经元损伤,加重RBI。目前RBI尚无有效治疗措施,明确其炎症作用途径,不但有利于阐明其发病机制,还将揭示有效的治疗靶点。近年来,对RBI发病和发展的分子机制研究有了较大进展,在此过程中起关键作用的炎症反应已被确定,且被认为是潜在的治疗靶点。同时,一系列不同种类和不同作用机制的药物的疗效也通过细胞及动物实验被验证,但缺乏有效的临床证据。然而,大多数研究都是独立进行的,缺乏系统性认识。本文就相关的炎症细胞及炎症因子等在RBI中的相互作用机制进行综述,为进一步探索RBI的发生发展机制及为未来临床防治放射性脑损伤提供理论依据。
Radiation-induced brain injury(RBI) is a serious complication after radiotherapy for primary or secondary head and neck tumors that impairs the long-term health of patients after radiotherapy and increases mortality in these patients. Brain radiotherapy can cause long-term and chronic inflammatory responses in the brain, and sustained inflammatory responses lead to neuronal dysfunction and cell death. Glial cell activation, microglial activation and the production of inflammatory factors can promote neuroinflammatory response, cause neuronal injury, and aggravate RBI. At present, there is no effective therapeutic measure for RBI, and clarifying its inflammatory pathway is not only conducive to elucidating its pathogenesis, but also will reveal effective therapeutic targets. In recent years, great progress has been made in the study of the molecular mechanisms of the pathogenesis and development of RBI, and the inflammatory response with a key role in this process has been identified and is considered a potential therapeutic target. At the same time, the efficacy of a series of drugs with different types and different mechanisms of action has also been verified through cellular and animal experiments, but effective clinical evidence is lacking. However, most studies have been conducted independently and lack systematic understanding. This article reviews the interaction mechanism of inflammatory cells and inflammatory factors in RBI providing a theoretical basis for further exploration of the mechanism of occurrence and development of RBI and future clinical prevention and treatment of radiation-induced brain injury.