文献类型：期刊文献

中文题名：2013-2023年溃疡性结肠炎相关信号通路研究文献可视化分析

英文题名：Visualization Analysis on Literature about Ulcerative Colitis-related Signaling Pathways from 2013 to 2023

作者：牟飞燕[1];柳芹芹[1];史树勋[2];张大涛[2]

第一作者：牟飞燕

机构：[1]甘肃中医药大学中医临床学院,甘肃兰州730000;[2]甘肃中医药大学附属医院,甘肃兰州730000

第一机构：甘肃中医药大学中医临床学院

年份：2024

卷号：48

期号：5

起止页码：105

中文期刊名：中国中医药图书情报杂志

外文期刊名：Chinese Journal of Library and Information Science for Traditional Chinese Medicine

基金：甘肃省中医药科研课题(GZKP-2020-33);国家医疗质量循证管理持续改进研究项目(YLZLXZ22G029);甘肃省卫生健康行业科研项目(GSWSKY2022-87)。

语种：中文

中文关键词：溃疡性结肠炎;信号通路;可视化分析;文献计量学

外文关键词：ulcerative colitis;signaling pathways;visualization analysis;bibliometrics

摘要：目的探讨2013-2023年溃疡性结肠炎(UC)相关信号通路研究现状及趋势。方法检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(VIP)2013年1月1日-2023年6月30日收录的UC相关信号通路研究文献,使用Excel2021软件统计年发文量,使用CiteSpace6.2.R4软件分析作者、研究机构、关键词,并绘制知识图谱。结果共纳入文献657篇,年发文量持续增长,发文量较高的作者为闫曙光、惠毅,发文量较高的研究机构为广西中医药大学、湖南中医药大学。高频关键词为“作用机制”“分子对接”“动物实验”“代谢组学”等,关键词共聚为7类,“分子对接”“作用机制”“凋亡”成为近10年突现关键词。结论该领域尚未形成核心作者群体,机构间合作较少;近10年来UC相关信号通路的研究热度呈持续状态,在UC炎症反应、氧化应激、细胞凋亡等方面的调控机制备受关注。作用机制仍是该领域研究重点,偏向于分子层面,需要更为高质量的实验研究和临床研究进一步验证。
Objective To explored the current research status and trend of ulcerative colitis-related(UC)signalling pathways from 2013 to 2023.Methods Literature about UC signalling pathways was retrieved from CNKI,Wanfang Data and VIP from January 1,2013 to June 30,2023.Excel 2021 software was used to count the annual number of publications.Citespace 6.2.R4 software was used to analyze authors,research institutions,keywords,and a knowledge graph was drawn.Results A total of 657 articles were included,and the annual publication volume continued to improve.The authors with higher publication volume were Yan Shuguang and Hui Yi,and the research institutions with higher publication volume were Guangxi University of Chinese Medicine and Hunan University of Chinese Medicine.High-frequency keywords were“mechanism”,“molecular docking”,“animal experiments”,“metabolomics”,etc.,and the keywords were clustered into 7 categories.The keywords of“molecular docking”,“mechanism”and“apoptosis”have become the keywords in the past 10 years.Conclusion The field has no formed core group of authors yet,and there is still little inter-institutional co-operation.In the past 10 years,the research on signaling pathways relevant to UC has been continuing,and the regulatory mechanisms of UC inflammatory response,oxidative stress,and apoptosis have attracted a high degree of attention.Mechanisms are still the focus of research in this field,which is oriented towards the molecular level and needs to be further verified by more high-quality laboratory and clinical studies.