文献类型：期刊文献

中文题名：镍及其合金植入大鼠体内后镍的代谢变化

英文题名：THE CHANGES OF NICKEL METABOLISM AFTER THE IMPLANTATION OF NICKEL AND NiTi SHAPE MEMORY ALLOY IN RATS

作者：赵英[1];郭文杰[1];宋焱峰[1];侯一平[1]

第一作者：赵英

机构：[1]甘肃中医学院人体解剖与组胚研究所,兰州730000

第一机构：甘肃中医药大学基础医学院（敦煌医学研究所）

年份：2007

卷号：34

期号：20

起止页码：3830

中文期刊名：现代预防医学

外文期刊名：Modern Preventive Medicine

收录：CSTPCD;;北大核心:【北大核心2004】；

基金：金川公司预研基金资助项目(20051117)

语种：中文

中文关键词：镍;镍钛形状记忆合金;体内植入;代谢;大鼠

外文关键词：Nickel; NiTi SMA; Implantation in vivo; Metabolism; Rat

摘要：[目的]观察大鼠体内长期植入镍(Nickel,Ni)和镍钛形状记忆合金(NiTi SMA)后机体内Ni元素的代谢状况。[方法]在大鼠后肢肌肉内植入Ni及NiTi SMA后饲养60 d,收集粪、尿,并取血、肾脏,火焰法原子吸收分光光度仪(SPAA)检测其中Ni含量。[结果]Ni组大鼠血、肾、尿、粪中Ni含量均高于对照组(P﹤0.01);NiTi组大鼠血Ni和尿Ni增高与对照组相比有统计学意义(P﹤0.05);粪和尿中Ni含量之间存在正相关(r=0.457,P﹤0.01)。Ni组大鼠肾脏在光镜下可见病理性改变。[结论]金属Ni和NiTi SMA长期植入大鼠体内均可导致机体内Ni含量增高,Ni主要经肾脏排出,部分由消化道排出,Ni在肾脏蓄积,并能导致肾结构和功能的破坏。
[Objective ] To investigate nickel （Ni） metabolism after the implantation of nickel and titanium shape memory alloy （NiTiSMA） in rats＇ bodies. [Methods] Ni and NiTi SMA were implanted respectively into the muscle of the right hind limbs of rats firstly, then the samples of urine, feces, blood, and kidney during 60 days of feeding were collected to detect the contents of nickel by using atomic absorption spectrophotometer. [ Results] The contents of Ni in blood, kidney, urine, and feces in Ni group were significantly higher than those in the control group （P〈 0.01 ） ; the contents of Ni in blood and urine in NiTi group increased significantly in comparison with the control group （P 〈 0.05）. There was positive conelation about the contents of Ni between in urine and in feces （r = 0.457, P 〈 0.01 ）. Pathological changes were observed under light microscope in histological sections of rat kidneys in Ni group. [ Conclusions] The study shows that long term implantation of nickel and NiTi SMA in rat can lead to the increase of Ni content in blood, urine and feces. Ni is eliminated mainly by kidney, some by digestive tract. Ni is accumulated in kidney and can damage the structure and function of kidney.