文献类型：期刊文献

中文题名：艾灸结合中西药对2型糖尿病患者神经内分泌免疫网络紊乱的调节作用研究

英文题名：Analysis on the Influence of Moxibustion Combines Chinese and Western Medicine the Regulation of Neuroendocrine Immune Network Disorder in Type 2 Diabetic Patients

作者：高妍[1];王涛[2];吴巧凤[3]

第一作者：高妍

机构：[1]甘肃中医药大学附属医院治未病体检中心,甘肃兰州730020;[2]甘肃省定西市渭源县中西医结合医院,甘肃定西748201;[3]成都中医药大学针灸推拿学院,四川成都610000

第一机构：甘肃中医药大学第二附属医院

年份：2019

卷号：30

期号：4

起止页码：908

中文期刊名：时珍国医国药

外文期刊名：Lishizhen Medicine and Materia Medica Research

收录：北大核心:【北大核心2017】；CSCD:【CSCD_E2019_2020】；

基金：国家自然科学基金(81373737;81330087)

语种：中文

中文关键词：穴位艾灸;2型糖尿病;神经内分泌;免疫网络紊乱

外文关键词：Acupoint moxibustion;Type 2 diabetes;Neuroendocrine;Immune network disorder

摘要：目的探讨穴位艾灸结合中西药治疗2型糖尿病患者的临床疗效及对患者神经内分泌免疫网络紊乱的调节作用。方法选取我院收治的2型糖尿病患者64例,采用随机数字表法平均分为两组,即对照组与研究组。两组患者均给予中西医治疗,研究组在对照组的基础上加用穴位艾灸,疗程3个月,比较两组患者治疗的有效性和神经内分泌免疫的各项指标。结果研究组总有效率为93.75%(30/32),对照组为78.13%(25/32),两组患者总有效率具有明显差异,P<0.05,研究组患者经治疗后血清DA、NE、IL-1、IL-6及TNF-α的含量较治疗前显著下降,CD4^+、CD8^+及NK细胞数量较治疗前显著上升(P<0.01),且明显优于对照组(P均<0.05),差异具有统计意义。结论穴位艾灸辅助治疗2型糖尿病疗效明显,其机制可能与改善神经内分泌免疫网络紊乱状态有关,对神经内分泌免疫网络紊乱有调节作用,值得推广应用。
Objective To investigate the clinical effect of acupoint moxibustion on the treatment of type 2 diabetes mellitus and its regulation effect on the disturbance of neuroendocrine immune network in patients. Methods A total of 64 patients with type 2 diabetes admitted to our hospital from March 2016 to August 2017 were randomly divided into two groups, the control group and the treatment group, each with 32 cases. Both groups were treated with Chinese and western medicine, and the team used acupoint moxibustion on the basis of the control group for 3 months, to compare the efficacy of treatment in two groups and the indicators of neuroendocrine immunity.Results The total effective rate of treatment group was 93.75%(30/32), while the control group was 78.13%(25/32). The total effective rate of the two groups was significantly different(P< 0.05), and the difference was statistically significant. Treatment group after treatment than before treatment the serum content of DA, NE up;IL-6, IL-1, cut down the content of TNF alpha, CD4^+, CD8^+ and NK cells quantity increased(P< 0.01), and is superior to the control group(P< 0.05), the difference has statistical significance. Conclusion Acupuncture moxibustion auxiliary curative effect in the treatment of type 2 diabetes, its mechanism may be related to improvement of neuroendocrine immune network state of disorder, disorder of neuroendocrine immune network has regulating effect, is worthy of popularization and application.