文献类型：期刊文献

英文题名：A One-Pot, Three-Component Synthesis of β,γ-Unsaturated α-Aminonitriles Using TMSCN as the Cyanide Source

作者：Niu, Pengxian[1];Wen, Fei[2];Chen, Guangyuan[2];Liu, Tujun[2];Ding, Zhe[3]

第一作者：牛鹏贤

通信作者：Wen, F[1]

机构：[1]Gansu Univ Chinese Med, Sch Pharm, Lanzhou 730000, Gansu, Peoples R China;[2]Lanzhou Resources & Environm Voc Tech Univ, Yellow River Basin Ecotope Integrat Ind & Educ Res, Lanzhou 730022, Gansu, Peoples R China;[3]Chinese Acad Sci, Northwest Inst Ecoenvironm & Resources, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Lanzhou Resources & Environm Voc Tech Univ, Yellow River Basin Ecotope Integrat Ind & Educ Res, Lanzhou 730022, Gansu, Peoples R China.

年份：2025

外文期刊名：SYNLETT

收录：;Scopus(收录号：2-s2.0-105000147304);WOS:【SCI-EXPANDED(收录号:WOS:001443152300001)】；

基金：We thank the Lanzhou Resources & Environment Voc-Tech UniversityKey Talent Support Program (X2024ZD-02), the Gansu Province University Youth Doctoral Support Project (2023QB-022) and the Natural Science Foundation of Gansu Province (23JRRA655) for financial support.

语种：英文

外文关键词：alpha-aminonitriles; trimethylsilyl cyanide; cyanide source; catalyst-free; cinnamaldehyde

摘要：An efficient method for synthesizing (3,y-unsaturated alpha-aminonitriles via a one-pot procedure using cinnamaldehydes, anilines and trimethylsilyl cyanide (TMSCN) as starting materials under catalyst- free conditions is reported. This one-pot, three-component reaction proceeds efficiently with a broad range of substrates and tolerates a wide variety of functional groups. Notably, the process features a simple work-up procedure and does not require transition-metal catalysts. Additionally, the reaction can be performed on gram scale without loss of efficiency.