文献类型：期刊文献

中文题名：长链非编码RNA调控肝癌干细胞的作用

英文题名：Long Non-coding RNA Regulates Liver Cancer Stem Cells

作者：马睿玲[1];王新斌[1];张秋菊[2];伊琳[1]

第一作者：马睿玲

机构：[1]甘肃中医药大学中西医结合学院,甘肃兰州730000;[2]甘肃中医药大学基础医学院,甘肃兰州730000

第一机构：甘肃中医药大学中西医结合学院

年份：2020

卷号：26

期号：4

起止页码：341

中文期刊名：肿瘤学杂志

外文期刊名：Journal of Chinese Oncology

收录：CSTPCD

基金：甘肃省自然科学基金项目(1508RJZA017)。

语种：中文

中文关键词：长链非编码RNA;肝癌干细胞;肝肿瘤

外文关键词：Long non-coding RNA;liver cancer stem cells;liver cancer

摘要：目前常规疗法对晚期、转移或复发肝癌患者疗效差。肝癌干细胞(LCSCs)参与肝癌的发展、侵袭、转移和耐药,与不良预后密切相关,被认为是肝癌治疗的重要靶点。长链非编码RNA(LncRNA)在肝癌中异常表达。最近的研究表明,lncRNAs可能在调控LCSCs的生物学功能中发挥重要作用。全文总结lncRNA调控LCSCs作用的研究现状。
Conventional therapies have very limited efficacy for advanced,metastatic or recurrent liver cancer patients. The liver cancer stem cells(LCSCs) are involved in the development,invasion,metastasis and drug resistance of hepatocellular carcinoma,and are closely related to the poor prognosis of patients. Therefore the LCSCs are considered as an important target for the treatment of liver cancer. Long non-coding RNA(Lnc RNA) is abnormally expressed in liver cancer. Recent studies have shown that Lnc RNAs may play an important role in regulating the biological function of LCSCs. In this review,the current research advances on the role of Lnc RNA in the regulation of LCSCs are summarized.