文献类型：期刊文献

英文题名：Interfacial Engineering of Pillararene-Modified Ceria Nanoparticles for Regulable Enhanced Sonodynamic Therapy

作者：Wang, Congcong[1];Guo, Yanan[1];Tan, Guoying[1];Kang, Wanrong[2];Guo, Wenjia[3];Song, Nan[1];Tang, Yu[1,4]

第一作者：Wang, Congcong

通信作者：Song, N[1];Tang, Y[1];Tang, Y[2]

机构：[1]Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat G, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Gansu Key Lab Pharmacol & Toxicol Tradit Chinese M, Lanzhou, Peoples R China;[3]Lanzhou Univ, Electron Microscopy Ctr, Lanzhou, Peoples R China;[4]Baotou Res Inst Rare Earths, State Key Lab Baiyunobo Rare Earth Resource Res &, Baotou, Peoples R China

第一机构：Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat G, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat G, Lanzhou, Peoples R China;[2]corresponding author), Baotou Res Inst Rare Earths, State Key Lab Baiyunobo Rare Earth Resource Res &, Baotou, Peoples R China.

年份：2025

外文期刊名：AGGREGATE

收录：EI(收录号：20252118452441);Scopus(收录号：2-s2.0-105005276422);WOS:【ESCI(收录号:WOS:001485961900001)】；

基金：This work was financially supported by the National Natural Science Foundation of China (projects 22221001, 22131007, and 22401119) and the 111 project (B20027), the Gansu provincial science and technology program (24ZD13GA015, 23ZDGA012, and 24JRRA435), and the Fundamental Research Funds for the Central Universities (lzujbky-2024-jdzx13).

语种：英文

外文关键词：ceria oxide; interfacial interaction; pillararenes; regulation; sonodynamic therapy

摘要：Sonodynamic therapy (SDT) has emerged as an advanced technology for treatment of malignant tumors. Many organic and inorganic sonosensitizers have been reported but they still have the respective limitations. Constructing the materials to integrate the superiorities of organic and inorganic sonosensitizers is expected to be a good method to enhance the efficiency of SDT. Herein, we report an intelligent sonosensitizer (TPA-OS subset of CP5@CeOx), integrating the organic (TPA-OS) and inorganic sonosensitizers (CP5@CeOx) via host-guest interaction. The modification of carboxyl-pillar[5]arene (CP5) on CeOx constructs the supramolecular interface by coupling of CP5 and oxygen vacancies. The band gap of CeOx is reduced and the ratio of Ce4+/Ce3+ is increased to regulate tumor microenvironment. Thus, the SDT performance of CP5@CeOx can be improved. Furthermore, the synergistic effect of TPA-OS with aggregation-induced emission can further regulate and enhance the SDT efficiency. The cellular experiments demonstrate that TPA-OS subset of CP5@CeOx exhibits the synergistic therapeutic effect in double organelle of lysosome and mitochondria. The in vivo experiments suggest TPA-OS subset of CP5@CeOx has imaging-guided enhanced SDT performance to achieve tumor inhibition. This study contributes to the construction of novel intelligent sonosensitizers, indicating that supramolecular interface engineering is promising to realize the customized treatments with minimal side effects.