文献类型：期刊文献

英文题名：Bolting reduces ferulic acid and flavonoid biosynthesis and induces root lignification in Angelica sinensis

作者：Li, Meiling[1];Cui, Xiuwen[1];Jin, Ling[2];Li, Mengfei[1];Wei, Jianhe[3]

第一作者：Li, Meiling

通信作者：Li, MF[1];Wei, JH[2]

机构：[1]Gansu Agr Univ, Coll Life Sci & Technol, Key Lab Aridland Crop Sci, Lanzhou 730070, Peoples R China;[2]Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Peoples R China;[3]Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Beijing 100193, Peoples R China

第一机构：Gansu Agr Univ, Coll Life Sci & Technol, Key Lab Aridland Crop Sci, Lanzhou 730070, Peoples R China

通信机构：[1]corresponding author), Gansu Agr Univ, Coll Life Sci & Technol, Key Lab Aridland Crop Sci, Lanzhou 730070, Peoples R China;[2]corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Beijing 100193, Peoples R China.

年份：2022

卷号：170

起止页码：171

外文期刊名：PLANT PHYSIOLOGY AND BIOCHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000783313100001)】；

基金：This work was financially supported by funds from State Key Laboratory of Aridland Crop Science Gansu Agricultural University (GSCS-2021-Z03) , National Natural Science Foundation of China (32160083) , China Agriculture Research System of MOF and MARA (CARS-21) , Key talent projects of Gansu Province (2020RCXM103) , and Assurance Project of Ecological Planting and Quality of Daodi Herbs (202103003) .

语种：英文

外文关键词：Angelica sinensis; Bolting; Ferulic acid; Flavonoids; Lignin; Gene expression

摘要：Angelica sinensis is a perennial herbaceous species that produces the bioactive metabolites ferulic acid and alkylphthalides widely applied in the treatment of cardio-cerebrovascular diseases. While the effects of bolting on plant biomass and metabolites accumulation have been partly investigated, the mechanism of bolting reducing metabolites biosynthesis is still limited. In this study, the root biomass, accumulations of ferulic acid, flavonoids and lignin, antioxidant capacity, and related genes expression at four different bolting stages were investigated. The results showed that there was a 2.2-, 2.4-and 2.9-fold decrease of the root biomass, ferulic acid and flavonoids contents, while a 2.9-fold increase of lignin content on a per plant basis during the bolting stages. The antioxidant capacity also exhibited significant decrease with growth and development. The differential expression levels of the 20 genes, which are involved in biosynthesis of ferulic acid (e.g. AsPAL1, As4CLs and AsHCT), flavonoids (e.g. AsCHS, AsCHI and AsI3 & PRIME;H) and lignin (e.g. AsCAD1 and AsLACs), were consistent with changes in the above metabolites accumulation. The findings will provide useful references for improving the production of bioactive metabolites in A. sinensis.