文献类型：期刊文献

英文题名：Hypoxia-inducible factor-1 (HIF-1) in the molecular mechanisms of liver fibrosis: research progress on its role and therapeutic strategies

作者：Zhou, Caiyun[1];Wang, Li[1]

第一作者：Zhou, Caiyun

通信作者：Zhou, CY[1];Wang, L[1]

机构：[1]Gansu Univ Tradit Chinese Med, Peoples Hosp Lanzhou 2, Dept Lab Med, Lanzhou Hosp 2, Lanzhou 730046, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Peoples Hosp Lanzhou 2, Dept Lab Med, Lanzhou Hosp 2, Lanzhou 730046, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2026

外文期刊名：JOURNAL OF APPLIED GENETICS

收录：;Scopus(收录号：2-s2.0-105047487712);WOS:【SCI-EXPANDED(收录号:WOS:001847386700001)】；

语种：英文

外文关键词：Hypoxia-inducible factor-1; Liver fibrosis; Hepatic stellate cells; Molecular mechanisms; Therapeutic strategies; Inflammatory response; HIF-1 inhibitors

摘要：Liver fibrosis, as a common pathological process in various chronic liver diseases, severely impacts patients' quality of life and prognosis. The core mechanisms driving its progression involve the activation of hepatic stellate cells (HSCs), sustained inflammatory responses, and cellular metabolic reprogramming. Within this process, hypoxia-inducible factor-1 (HIF-1), a key transcription factor enabling cellular adaptation to hypoxic environments, has been shown to play a significant role. Current research further demonstrates that HIF-1 participates in multiple molecular mechanisms of liver fibrosis by regulating HSC activation, promoting inflammation, and modulating metabolic pathways. However, the precise regulatory networks of HIF-1 in liver fibrosis and effective intervention strategies remain poorly understood.Therefore, this article systematically reviews the molecular regulatory network of HIF-1 in liver fibrosis, with a particular focus on its role in cell apoptosis and metabolic reprogramming. Furthermore, it summarizes recent advances in therapeutic strategies targeting HIF-1 and its related signaling pathways, including the development and application of HIF-1 inhibitors, natural products, and small-molecule drugs. In summary, by integrating the latest basic and clinical research findings, this review aims to provide theoretical support and identify future research directions for targeted therapy of liver fibrosis, thereby facilitating the clinical translation of relevant treatment approaches.