文献类型：期刊文献

英文题名：Analysis of garlic intake on atrophic gastritis risk in different infectious states of Helicobacter pylori in a case-control study

作者：Wu, Jianjun[1,2,3];Zhang, Jia[1,2,3];Jin, Lan[4];Wei, Xingmin[1,2,3];Liu, Yuqin[5]

第一作者：吴建军;Wu, Jianjun

通信作者：Liu, YQ[1]

机构：[1]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou 730000, Gansu Province, Peoples R China;[2]Key Lab Dunhuang Med & Transformat Prov & Minister, Lanzhou 730000, Gansu Province, Peoples R China;[3]Gansu Univ Chinese Med, Inst Prevent Med Tradit Chinese Med, Lanzhou 730000, Gansu Province, Peoples R China;[4]Yale Univ, Sch Med, New Haven, CT USA;[5]Gansu Canc Hosp, Canc Epidemiol Lab, Lanzhou 730000, Gansu Province, Peoples R China

第一机构：甘肃中医药大学公共卫生学院

通信机构：[1]corresponding author), Gansu Canc Hosp, Canc Epidemiol Lab, Lanzhou 730000, Gansu Province, Peoples R China.

年份：2025

卷号：15

期号：1

外文期刊名：SCIENTIFIC REPORTS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001443941100002)】；

基金：We thank the participatory patients and their supportive families, as well as our colleagues and Tumor Registration Area of Gansu Province.

语种：英文

外文关键词：Atrophic gastritis; H. pylori; Different infectious States; Garlic intake; Case-control study

摘要：In this case-control study, the main risk factors for atrophic gastritis (AG) were comprehensively analyzed in a real-world environment to identify potential risk factors associated with garlic intake and its effects on AG. Design Upper gastrointestinal endoscopy and pathological examination were performed as part of a gastric cancer screening and health check-up program. The detailed characteristics of both the case group and healthy control group were recorded and analyzed. All participants were fasted for at least 4 h and a urea breath test13C-UBT) was performed in all participants at rest. Both univariate and multivariate logistic regression analyses were performed and presented as the odds ratio (OR) and 95% confidential interval (CI), with additional subgroup analysis stratified by infectious state based on the presence, eradication or absence of H. pylori. Setting Gansu Province in China. Participants 10,035 people from Gansu Province in China were included. Among 7,058 participants, 4,712 (66.8%) had AG. Garlic intake was a significant risk factor for AG in participants currently (infected state) or previously (eradicated state) infected with H. pylori (OR = 1.39, 95% CI: 1.06-1.83; OR = 1.16, 95% CI = 1.01-1.32). Garlic intake was not significantly associated with AG in participants without H. pylori' s infection (OR = 1.14, 95% CI: 0.88-1.46). The association between garlic intake and AG differed by H. pylori infectious state. People in the infected or eradicated states are at a higher risk for AG associated with garlic intake. Diet may regulate the pathogenic role of H. pylori and intestinal flora.