文献类型：期刊文献

英文题名：The gut-kidney axis in urolithiasis: roles of gut microbiota, metabolites, and therapeutic implications

作者：Li, Dong[1];Li, Zehong[1];Liu, Wei[1]

第一作者：董莉

通信作者：Liu, W[1]

机构：[1]Gansu Univ Chinese Med, Affiliated Hosp 3, Dept Urol Surg, Baiyin, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp 3, Dept Urol Surg, Baiyin, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：16

外文期刊名：FRONTIERS IN MICROBIOLOGY

收录：;Scopus(收录号：2-s2.0-105019651310);WOS:【SCI-EXPANDED(收录号:WOS:001599393000001)】；

基金：The author(s) declare that financial support was received for the research and/or publication of this article. This work was supported by Research Project of the First People's Hospital of Baiyin City (Title: Study on the Correlation between the Degree of Renal Colic Pain and Clinical Factors) Project Number: 2021YK-09.

语种：英文

外文关键词：gut-kidney axis; urolithiasis; gut microbiota; oxalate metabolism; short-chain fatty acids; probiotics; prebiotics; fecal microbiota transplantation

摘要：Urolithiasis affects 2-20% of the global population and recurs frequently. Emerging evidence positions the gut-kidney axis as a central driver of stone formation. This review synthesizes epidemiological data, comparative metagenomic analyzes, and mechanistic studies to demonstrate that stone formers exhibit reduced alpha-diversity, depletion of oxalate-degrading taxa (e.g., Oxalobacter, Lactobacillus, Bifidobacterium), and enrichment of pro-inflammatory genera (Escherichia, Bacteroides). Microbial metabolites-oxalate, short-chain fatty acids, p-cresol, and secondary bile acids-modulate intestinal oxalate transport, systemic inflammation, and renal crystal nucleation. Therapeutic modulation via targeted probiotics, prebiotics, engineered Lactobacillus, or fecal microbiota transplantation restores oxalate homeostasis and attenuates nephrolithiasis in rodent models; however, human efficacy remains preliminary. Large-scale multi-omics cohorts and randomized controlled intervention trials are imperative to translate gut-centric strategies into precision urology.